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108975

Sigma-Aldrich

Leupeptin, Hemisulfate, Microbial

Leupeptin hemisulfate, CAS 103476-89-7, is a reversible inhibitor of trypsin-like proteases and cysteine proteases

Sinônimo(s):

Leupeptin, Hemisulfate, Microbial, Ac-LLR-CHO, ½H₂SO₄

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About This Item

Fórmula empírica (Notação de Hill):
C20H38N6O4 · 0.5H2SO4
Número CAS:
Peso molecular:
475.59
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.77

Nível de qualidade

descrição

Merck USA index - 14, 5456

Ensaio

≥90% (HPLC)

Formulário

lyophilized solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze
desiccated (hygroscopic)

cor

white

solubilidade

water: 50 mg/mL

Condições de expedição

ambient

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[N+H](=C(N)N)CCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)C)CC(C)C)CC(C)C)C=O

InChI

1S/C20H38N6O4/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23)/p+1/t15-,16-,17-/m0/s1

chave InChI

GDBQQVLCIARPGH-ULQDDVLXSA-O

Descrição geral

A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.
A reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors. Also available as a 50 mM solution in H2O (Cat. No. 509281).

Ações bioquímicas/fisiológicas

Cell permeable: no
Primary Target
trypsin- and cysteine-like proteases
Product does not compete with ATP.
Reversible: yes

Advertência

Toxicity: Standard Handling (A)

Sequência

Ac-Leu-Leu-arginal, hemisulfate

Reconstituição

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Outras notas

Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
Sarin, A., et al. 1994. J. Immunol.153, 862.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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