860516P

C16 Ceramide (d18:1/16:0)

Avanti Research^™ - A Croda Brand

• Sinônimo(s): N-palmitoyl-D-erythro-sphingosine
• Fórmula empírica (Notação de Hill): C₃₄H₆₇NO₃
• Número CAS: 24696-26-2
• Peso molecular: 537.90
• Número MDL: MFCD00871748
• Código UNSPSC: 12352211
• NACRES: NA.25

Propriedades

• Formulário: powder
• embalagem: pkg of 1 × 10 mg (860516P-10mg); pkg of 1 × 100 mg (860516P-100mg); pkg of 1 × 25 mg (860516P-25mg); pkg of 1 × 5 mg (860516P-5mg); pkg of 1 × 50 mg (860516P-50mg)
• fabricante/nome comercial: Avanti Research^™ - A Croda Brand
• tipo de lipídio: sphingolipids
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OC[C@]([H])(NC(CCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C34H67NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h27,29,32-33,36-37H,3-26,28,30-31H2,1-2H3,(H,35,38)/b29-27+/t32-,33+/m0/s1
• chave InChI: YDNKGFDKKRUKPY-TURZORIXSA-N

Descrição

Descrição geral

Ceramide comprise sphingosine and fatty acid and belongs to the sphingolipids family.[1]

Aplicação

C16 Ceramide (d18:1/16:0) has been used:

• as an internal standard in the chromatography with negative ion electrospray ionization coupled to tandem mass spectrometry for myocardial ceramide quantification[2]
• as an internal standard for the ceramide quantification from rat samples using liquid chromatography-mass spectrometry[3]
• to test its effect on mitochondrial stress response in worms[4]

Ações bioquímicas/fisiológicas

C16 Ceramide levels are elevated in chronic alcohol-related liver disease (ALD). In general, ceramide inhibits mitochondrial function and insulin signaling. They are essential component of cell membrane and are involved in lipid raft formation.[1] C16 ceramide based analog (C2-C16 CCPS) is potential anticancer agent used in chemotherapy.[5] The levels of C16 ceramide and its ratio with other ceramides is regarded as a biomarker in predicting coronary artery disease (CAD).[6] It interacts with the DNA-binding domain of tumor suppressor protein p53 and activates p53.[7]

Embalagem

5 mL Amber Glass Screw Cap Vial (860516P-100mg)

5 mL Amber Glass Screw Cap Vial (860516P-10mg)

5 mL Amber Glass Screw Cap Vial (860516P-25mg)

5 mL Amber Glass Screw Cap Vial (860516P-50mg)

5 mL Amber Glass Screw Cap Vial (860516P-5mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable