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22244

Sigma-Aldrich

Ceramide from bovine spinal cord

≥98.0% (TLC)

Sinônimo(s):

Bovine Spinal Cord Ceramide

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About This Item

Número MDL:
MFCD00146359
Código UNSPSC:
12352211
NACRES:
NA.25

fonte biológica

bovine spinal cord

Ensaio

≥98.0% (TLC)

forma

solid

Impurezas

α-hydroxy fatty acids

solubilidade

chloroform/methanol (99:1): 20 mg/mL, clear, colorless

tipo de lipídio

sphingolipids

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

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Aplicação

Ceramide is used to investigate effects on programmed cell death (apoptosis) and insulin signaling.

Ações bioquímicas/fisiológicas

Ceramide is a minor component of cell membranes. Activates atypical protein kinase C (e.g., PKCzeta) .

Nota de preparo

from cerebrosides by a modification of the procedure by H.E. Carter et al., J. Lipid Res. 2, 228 (1961)

Outras notas

Sales restrictions may apply

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Darren J Powell et al.
Molecular and cellular biology, 23(21), 7794-7808 (2003-10-16)
Ceramide is generated in response to numerous stress-inducing stimuli and has been implicated in the regulation of diverse cellular responses, including cell death, differentiation, and insulin sensitivity. Recent evidence indicates that ceramide may regulate these responses by inhibiting the stimulus-mediated
M G Yefimova et al.
Human reproduction (Oxford, England), 35(6), 1346-1362 (2020-06-13)
Do human granulosa cells (GCs) ingest and destroy apoptotic oocytes? Somatic GCs ingest and destroy apoptotic oocytes and other apoptotic substrates through unconventional autophagy-assisted phagocytosis. Most (99%) ovarian germ cells undergo apoptosis through follicular atresia. The mode of cleaning of
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Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report in this study that the secretory ECM1a isoform induces tumorigenesis through the GPR motif binding to
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The EMBO journal, 36(22), 3356-3371 (2017-10-12)
In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques.

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