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860501P

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C22 Ceramide (d18:1/22:0)

Avanti Research™ - A Croda Brand 860501P, powder

Sinônimo(s):

N-behenoyl-D-erythro-sphingosine

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R$ 875,00
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R$ 1.562,00

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5 MG
R$ 875,00
10 MG
R$ 1.562,00

About This Item

Fórmula empírica (Notação de Hill):
C40H79NO3
Número CAS:
27888-44-4
Peso molecular:
622.06
Número MDL:
MFCD09840213
Código UNSPSC:
12352211
NACRES:
NA.25

R$ 875,00

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Formulário

powder

embalagem

pkg of 1 × 10 mg (860501P-10mg)
pkg of 1 × 5 mg (860501P-5mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 860501P

tipo de lipídio

sphingolipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC[C@]([H])(NC(CCCCCCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C40H79NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-24-26-28-30-32-34-36-40(44)41-38(37-42)39(43)35-33-31-29-27-25-23-16-14-12-10-8-6-4-2/h33,35,38-39,42-43H,3-32,34,36-37H2,1-2H3,(H,41,44)/b35-33+/t38-,39+/m0/s1

chave InChI

KEPQASGDXIEOIL-GLQCRSEXSA-N

Descrição geral

C22 Ceramide (d18:1/22:0) or N-behenoyl-D-erythro-sphingosine is a synthetic ceramide containing sphingosine with behenic acid.

Aplicação

C22 Ceramide (d18:1/22:0) has been used:
  • as a standard to measure ceramide concentrations in muscle tissue samples using high-performance liquid chromatography/tandem mass spectrometry (LC/MS2)[1]
  • as a standard for the quantitation of sphingolipid metabolites[2]
  • to study its effects on mitochondrial-to-cytosolic stress response (MCSR) induction[3]

Ações bioquímicas/fisiológicas

Ceramides plays an important role in regulating cell differentiation, proliferation and apoptosis. It also regulates stress responses and inflammation.[4]

Embalagem

5 mL Amber Glass Screw Cap Vial (860501P-10mg)
5 mL Amber Glass Screw Cap Vial (860501P-5mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

geralmente comprado junto com este produto

Nº do produto
Descrição
Preços

Código de classe de armazenamento

11 - Combustible Solids

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Sigma-Aldrich

43799

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Hyun-Eui Kim et al.
Cell, 166(6), 1539-1552 (2016-09-10)
Defects in mitochondrial metabolism have been increasingly linked with age-onset protein-misfolding diseases such as Alzheimer's, Parkinson's, and Huntington's. In response to protein-folding stress, compartment-specific unfolded protein responses (UPRs) within the ER, mitochondria, and cytosol work in parallel to ensure cellular
Mutay Aslan et al.
Nutrition and cancer, 1-13 (2020-04-15)
We aimed to investigate the impact of thymoquinone (TQ), on sphingolipid metabolites, ER stress and apoptotic pathways in MCF-7 and HepG2 cancer cells. Antiproliferative effect was exerted in cancer cells via TQ incubation at different doses and durations. Cell viability
Xingzhong Zhang et al.
Cell metabolism, 30(5), 937-951 (2019-11-02)
Obesity-induced adipose dysfunction is a major contributor to atherosclerosis. Cold exposure has been reported to affect atherosclerosis through regulation of adipose function, but the mechanism has not been well clarified. Here, adipocyte hypoxia-inducible factor 2α (HIF-2α) was upregulated after mild cold
Dimple Kauhanen et al.
Analytical and bioanalytical chemistry, 408(13), 3475-3483 (2016-02-29)
Monitoring the levels of the ceramides (Cer) d18:1/16:0, Cer d18:1/18:0, Cer d18:1/24:0, and Cer d18:1/24:1 and ratios thereof in human plasma empowers the prediction of fatal outcome of coronary artery disease (CAD). We describe a validated liquid chromatography-tandem mass spectrometry
Ebru Afşar et al.
Redox biology, 30, 101430-101430 (2020-01-25)
We aimed to determine sphingolipid levels and examine apoptotic pathways in human retinal pigment epithelial cells (ARPE-19) undergoing endoplasmic reticulum (ER) stress. Cells were treated with tunicamycin (TM) to induce ER stress and tauroursodeoxycholic acid (TUDCA), an ER stress inhibitor
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