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N3633

Sigma-Aldrich

β-Naphthoflavone

≥98%

Sinônimo(s):

beta-Naphthoflavone, 5,6-Benzoflavone, BNF

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About This Item

Fórmula empírica (Notação de Hill):
C19H12O2
Número CAS:
6051-87-2
Peso molecular:
272.30
Beilstein:
18991
Número CE:
227-958-4
Número MDL:
MFCD00004986
Código UNSPSC:
12352100
ID de substância PubChem:
57654450
NACRES:
NA.22

Ensaio

≥98%

cor

off-white to yellow

pf

164-166 °C (lit.)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O=C1C=C(Oc2ccc3ccccc3c12)c4ccccc4

InChI

1S/C19H12O2/c20-16-12-18(14-7-2-1-3-8-14)21-17-11-10-13-6-4-5-9-15(13)19(16)17/h1-12H

chave InChI

OUGIDAPQYNCXRA-UHFFFAOYSA-N

Informações sobre genes

rat ... Gabra2(29706)

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Descrição geral

β-Naphthoflavone is a polyaromatic hydrocarbon.

Aplicação

β-Naphthoflavone has been used:
  • as aryl hydrocarbon receptor agonist to elucidate its effect on Cyp1A1 expression in embryos of transgenic cytochrome P450 1A1 (cyp1a) reporter zebrafish
  • as AhR agonists, to treat primary normal human epidermal keratinocytes (NHEKs) to study about aryl hydrocarbon receptor (AhR) activation by western blot analysis
  • to determine its effect on the expression of dystrophin (Dp)71
  • to stimulate the expression of causes recombination (Cre) recombinase and to delete the flanking alleles of locus of crossing (x) over, P1 (loxP) sequences

Ações bioquímicas/fisiológicas

β-Naphthoflavone (BNF) is an exogenous ligand for aryl hydrocarbon receptor (AhR) in humans. It is an inducer of phase I detoxification enzymes (CYPs) and phase II enzymes (UDP-GTs) and NAD(P)H-dependent quinone oxyreductase-1(NQO1). It also induces cytochrome P450 (Cyp1a). BNF represses the expression of Duchenne muscular dystrophy gene, dystrophin (Dp)71 by altering the binding of the transcription factors.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Despite emerging evidence that disruption in circadian rhythms may contribute to the pathophysiology of psychiatric disorders, there is a significant knowledge gap on the rhythmicity of psychological symptoms. Here, we aimed at investigating the rhythmicity of mood symptoms in individuals
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