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Documentos Principais

R3501

Sigma-Aldrich

Rifampicina

≥95% (HPLC), powder or crystals

Sinônimo(s):

3-(4-Metilpiperaziniliminometil)rifamicina SV, Rifamicina AMP, Rifampina

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250 MG
R$ 664,00
1 G
R$ 1.470,00
5 G
R$ 4.724,00
25 G
R$ 20.814,00

R$ 664,00


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250 MG
R$ 664,00
1 G
R$ 1.470,00
5 G
R$ 4.724,00
25 G
R$ 20.814,00

About This Item

Fórmula empírica (Notação de Hill):
C43H58N4O12
Número CAS:
Peso molecular:
822.94
Beilstein:
5723476
Número CE:
Número MDL:
Código UNSPSC:
51283601
ID de substância PubChem:
NACRES:
NA.76

R$ 664,00


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Nível de qualidade

Ensaio

≥95% (HPLC)

Formulário

powder or crystals

cor

Reddish-brown

pKa 

1.7 (4-hydroxyl group)
7.9 (4-piperazine nitrogen)

pI 

4.84

espectro de atividade do antibiótico

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
viruses

Modo de ação

protein synthesis | interferes

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(\C=N\N5CCN(C)CC5)c(O)c4c3C2=O

InChI

1S/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20+/t21-,23+,24+,25+,29-,34-,35+,39+,43-/m0/s1

chave InChI

JQXXHWHPUNPDRT-WLSIYKJHSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

Estrutura química: macrolídeo

Aplicação

A rifampicina é usada para tratar a tuberculose e infecções micobacterianas relacionadas à tuberculose[1]. Ela é amplamente utilizada como agente antipruriginoso na doença hepática colestática autoimune, cirrose biliar primária (CBP). Demonstrou-se que causa hepatite[2].

Ações bioquímicas/fisiológicas

A rifampicina inibe a formação de DNA e proteínas em partículas virais maduras. Ela inibe o início da síntese de RNA ligando-se à subunidade β da RNA polimerase, o que leva à morte celular[1].
Inibe a formação de partículas virais maduras a partir de DNA e proteínas.
Modo de ação: Inibe o início da síntese de RNA ligando-se à subunidade β da RNA polimerase.

Outras notas

Mantenha o recipiente hermeticamente fechado, em local seco e bem ventilado. O produto é sensível à luz e à umidade. Armazene em gás inerte. Mantenha em local seco.

Pictogramas

Exclamation mark

Palavra indicadora

Warning

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves


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Certificados de análise (COA)

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Os clientes também visualizaram

M I Prince et al.
Gut, 50(3), 436-439 (2002-02-13)
There is evidence to suggest that rifampicin is an effective second line therapy for controlling pruritus in patients with chronic cholestatic liver disease. It is most widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary
Samy Figueiredo et al.
Antimicrobial agents and chemotherapy, 53(6), 2657-2659 (2009-03-25)
Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of
Sandra V Kik et al.
The Journal of infectious diseases, 211 Suppl 2, S58-S66 (2015-03-15)
The potential available market (PAM) for new diagnostics for tuberculosis that meet the specifications of the high-priority target product profiles (TPPs) is currently unknown. We estimated the PAM in 2020 in 4 high-burden countries (South Africa, Brazil, China, and India)
Toril Lindbäck et al.
Veterinary research, 41(1), 8-8 (2009-10-03)
Media-based bacteriological testing will fail to detect non-culturable organisms and the risk of consuming viable but non-culturable (VBNC) Listeria monocytogenes is unknown. We have here studied whether L. monocytogenes obtained from seafoods, processing environment and clinical cases enter the VBNC
Rodney Dawson et al.
Lancet (London, England), 385(9979), 1738-1747 (2015-03-22)
New antituberculosis regimens are urgently needed to shorten tuberculosis treatment. Following on from favourable assessment in a 2 week study, we investigated a novel regimen for efficacy and safety in drug-susceptible and multidrug-resistant (MDR) tuberculosis during the first 8 weeks

Artigos

Discover critical characteristics to consider when working with enzyme inhibitors, such as cell permeability, the prozone effect, and Lipinski’s rule of 5.

Questions

1–7 of 7 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What solvent should be used to reconstitute item R3501, Rifampicin?

    1 answer
    1. Rifampicin is soluble in CHCl3. Additionally, it is soluble in water at pH 4.3 (1.3 mg/ml), methanol (25 mg/ml), DMSO (25 mg/ml), dimethyl sulfoxide, tetrahydrofuran, and water at pH 7.3 (2.5 mg/ml at 25°C).

      Helpful?

  4. What is the difference between the various Rifampicin products available from Sigma-Aldrich?

    1 answer
    1. Sigma-Aldrich offers several Rifampicin products, each tested and best suited for specific applications.  The products range from a general use research grade to sterile powder, to plant culture tested.  See individual products for specific details.

      Helpful?

  5. How is the potency determined for Product R3501, Rifampicin?

    1 answer
    1. The potency is determined from a microbiological assay (USP XXII) for antibiotics, a 2-level assay. The test organism is Bacillus subtilis ATCC 6633. The minimum dose is 4.0 μg/ml and the maximum dose is 8.0 μg/ml.

      Helpful?

  6. The label advises that I should store Product R3501, Rifampicin, frozen. But when it arrived there was no ice in the package. Why is that?

    1 answer
    1. This product in its powder form is stable for short periods of time (i.e., the shipping process), at ambient temperature.  For long term storage it is best to store it at -20°C.

      Helpful?

  7. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

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