Y4895

YM-58483

≥98% (HPLC)

• Synonym(e): 4-methyl-4′-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide
• Empirische Formel (Hill-System): C₁₅H₉F₆N₅OS
• CAS-Nummer: 223499-30-7
• Molekulargewicht: 421.32
• MDL-Nummer: MFCD00220976
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329831590
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: Cc1nnsc1C(=O)Nc2ccc(cc2)-n3nc(cc3C(F)(F)F)C(F)(F)F
• InChI: 1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
• InChIKey: XPRZIORDEVHURQ-UHFFFAOYSA-N

Beschreibung

Anwendung

YM-58483 has been used in the inhibition studies of calcium channels present in cardiomyocytes[1] and pulmonary arterial endothelial cells.[2]

Biochem./physiol. Wirkung

Selective store operated calcium (SOC) channel inhibitor.

YM-58483 is a selective Ca⁺⁺ release-activated Ca⁺⁺ (CRAC) [a.k.a. store-operated Ca⁺⁺ (SOC) channels] that mediate Ca⁺⁺ influx in T cells and other inflammatory cells. CRAC channel inhibitors have potential clinical applications in autoimmune disease, transplant rejection, allergic airway inflammation and bronchial asthma. YM-58483 is also promoted as a tool for CRAC studies; may be used as a gold standard.

Leistungsmerkmale und Vorteile

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves