![Di-μ-chloro-dichloro-bis-[(1,2,3,4,5,6-η)-1,3,5-trimethylbenzol]-diruthenium 95%](/deepweb/assets/sigmaaldrich/product/structures/488/941/5acf0034-14a0-4448-a9e7-b4112e237d87/640/5acf0034-14a0-4448-a9e7-b4112e237d87.png)
The axial Chloride in Ru265 dissociates quickly in aqueous solutions, converting to the aquated Ru265' form. Solutions should be prepared fresh.
Fortfahren mit
SML2991
Ru265
≥95% (HPLC), powder, mitochondrial calcium uniporter inhibitor
Synonym(e):
Ru2(μ-N)(NH3)8Cl2]Cl3, trans,trans-Octaamminedichloro-μ-nitridodi-Ruthenium(3+) trichloride, Nitride, ruthenium complex
zur Ansicht der Organisations- und Vertragspreise.
Größe auswählen
Ansicht ändern
| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
5 mg | Warenkorb auf Verfügbarkeit prüfen | € 102,00 |
25 mg | Warenkorb auf Verfügbarkeit prüfen | € 413,00 |
Über diesen Artikel
Empirische Formel (Hill-System):
Cl5H24N9Ru2
CAS-Nummer:
Molekulargewicht:
529.66
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
powder
Technischer Dienst
Benötigen Sie Hilfe? Unser Team von erfahrenen Wissenschaftlern ist für Sie da.
Unterstützung erhaltenProduktname
Ru265, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to dark beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Cl[Ru](N)(N)(N)(N)n[Ru](N)(N)(N)(N)Cl
Biochem/physiol Actions
Ru265 is a non-cytotoxic, aqueous soluble nitrido-bridged dinuclear Ru(IV) complex that acts as a selective mitochondrial calcium uniporter (MCU) inhibitor via a manner distinct from the oxo-bridged Ru360. Ru265 selectively reduces 100 μM histamine-induced mitochondrial [Ca2+] (mCa2+), but not cytosolic [Ca2+] (cCa2+) transient (50 ?M; HeLa) by blocking MCU-mediated mCa2+ uptake at a >10-fold greater potency as Ru360 (IC50 ~2.6 nM vs. 30 nM; HEK293T) without effecting mCa2+ efflux or membrane potential (ΔΨm). Ru265 (50 μM) protects neonatal rat ventricular myocytes from hypoxia/reoxygenation injury by preventing mPTP opening and mCa2+ overload.
Selective mitochondrial calcium uniporter (MCU) inhibitor that blocks mitochondrial Ca2+ uptake at a >10-fold greater potency as Ru360.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| assay ≥95% (HPLC) | assay - | assay 95% | assay ≥99.9% trace metals basis |
| form powder | form powder | form crystals | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. - |
| solubility H2O: 2 mg/mL, clear | solubility H2O: slightly soluble(lit.) | solubility - | solubility acetone: soluble ((lit.)), ethanol: soluble, water: soluble |
| color white to dark beige | color - | color - | color - |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hier finden Sie alle aktuellen Versionen:
Besitzen Sie dieses Produkt bereits?
In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
-
Would the main stock of Ru265 prepared with H2O be safe for a month at -20C?
1 answer-
Helpful?
-
-
Is it possible to store in solution?
1 answer-
The solution stability of this product has not been evaluated. It is recommended to prepare fresh each time.
Helpful?
-