This compound is soluble in DMSO (> 10mg/ml).
T3077
TRO 19622
≥98% (HPLC), solid
Synonym(e):
NSC 21311, cholest-4-en-3-one, oxime
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5 MG
€ 152,00
25 MG
€ 662,00
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5 MG
€ 152,00
25 MG
€ 662,00
About This Item
Empirische Formel (Hill-System):
C27H45NO
CAS-Nummer:
Molekulargewicht:
399.65
UNSPSC-Code:
12352200
NACRES:
NA.77
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Qualitätsniveau
Assay
≥98% (HPLC)
Form
solid
Farbe
white
Löslichkeit
DMSO: >10 mg/mL
Lagertemp.
−20°C
InChI
1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+
InChIKey
QNTASHOAVRSLMD-SGWCAAJKSA-N
Anwendung
TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3.
Biochem./physiol. Wirkung
TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.
TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS).
Angaben zur Herstellung
TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Lee J Martin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(1), 359-370 (2011-01-07)
Ablation of mouse occipital cortex induces precisely timed and uniform p53-modulated and Bax-dependent apoptosis of thalamocortical projection neurons in the dorsal lateral geniculate nucleus (LGN) by 7 d after lesion. We tested the hypothesis that this neuronal apoptosis is initiated
Lyudmila I Rachek et al.
Toxicology and applied pharmacology, 240(3), 348-354 (2009-07-28)
Thiazolidinediones (TZDs), such as troglitazone (TRO) and rosiglitazone (ROSI), improve insulin resistance by acting as ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma). TRO was withdrawn from the market because of reports of serious hepatotoxicity. A growing body of
Thierry Bordet et al.
The Journal of pharmacology and experimental therapeutics, 322(2), 709-720 (2007-05-15)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive death of cortical and spinal motor neurons, for which there is no effective treatment. Using a cell-based assay for compounds capable of preventing motor neuron cell death in
Yiqiao Li et al.
The International journal of neuroscience, 123(11), 810-822 (2013-05-15)
Multiple sclerosis is a neurodegenerative autoimmune disease characterized by diffuse oligodendrocyte injury, axonal loss and multifocal demyelination of myelin sheaths in the central nervous system. TRO19622 is a small cholesterol-like compound, which displays remarkable neuroprotective and neuroregenerative properties in neural
Thierry Bordet et al.
The Journal of pharmacology and experimental therapeutics, 326(2), 623-632 (2008-05-22)
Diabetes and cancer chemotherapies are often associated with painful neuropathy. The mechanisms underlying neuropathic pain remain poorly understood, and the current therapies have limited efficacy and are associated with dose-limiting side effects. We recently described the pharmacological characterization of cholest-4-en-3-one
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What is the solubility of TRO 19622, Product T3077?
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the structure of TRO 19622, Product T3077?
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Please see the following reference for more information: T. Bordet et al., Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J. Pharmacol. Exp. Ther., 322, 709-720 (2007).
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How does TRO 19622, Product T3077 work?
1 answer-
TRO 19622 interacts with the mitochondrial permeability transition pore (mPTP). By interacting with protein components of the mPTP, it prevents the release of apoptotic factors and therefore protects the neuron. This mechanism of action may lead to a general neuroprotective activity. Please see the following reference for more information: T. Bordet et al., Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis J. Pharmacol. Exp. Ther. 322, 709-720, (2007)
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