T182

Tyrphostin A9

solid

• Synonym(e): Malonoben, [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile
• Empirische Formel (Hill-System): C₁₈H₂₂N₂O
• CAS-Nummer: 10537-47-0
• Molekulargewicht: 282.38
• NACRES: NA.77
• PubChem Substance ID: 24278069
• UNSPSC Code: 51111800
• MDL number: MFCD00209853
• Assay: ≥98% (HPLC)
• Form: solid

Eigenschaften

• biological source: synthetic (organic)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• color: yellow
• mp: 139-140 °C
• solubility: ethanol: 20 mg/mL, DMSO: <25 mg/mL, H₂O: insoluble
• SMILES string: CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C
• InChI: 1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3
• InChI key: MZOPWQKISXCCTP-UHFFFAOYSA-N
• Gene Information: human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159) ; mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779)

Beschreibung

Application

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells. It has also been used to disrupt membrane potential in mammalian cells.

Biochem/physiol Actions

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells, inhibit the growth of vascular smooth cells and block calcium release-dependent phosphorylations.

Features and Benefits

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Preparation Note

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311
• pcodes: P280 - P301 + P310 + P330 - P302 + P352 + P312
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Oral
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges