SRP6158
EPO human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
Synonym(e):
EP, EPO-alpha, Epoetin, Erythropoietin-alpha, MGC138142
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About This Item
Empfohlene Produkte
Biologische Quelle
human
Rekombinant
expressed in HEK 293 cells
Assay
≥95% (SDS-PAGE)
Form
lyophilized
Mol-Gew.
36 kDa (monomer, glycosylated)
Verpackung
pkg of 10 μg
Methode(n)
cell culture | mammalian: suitable
NCBI-Hinterlegungsnummer
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−70°C
Angaben zum Gen
human ... EPO(2056)
Allgemeine Beschreibung
The gene EPO (erythropoietin) is mapped to human chromosome 7q22. It is a glycoprotein hormone. EPO is generated in fetal liver and adult kidney. However, it can also be secreted by other organs, such as the heart, brain and lungs. EPO is a member of the EPO/TPO (thrombopoietin) family and is found in the plasma.
Anwendung
- EPO (erythropoietin) has been used as a component of the culture medium for cardiac stem cells.
- In cultured cerebellar granule cells and hippocampal neurons, it has been used to study effect of EPO on glutamate release.
- It has also been used as a component of endothelial differentiation medium.
Biochem./physiol. Wirkung
EPO (erythropoietin) regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. It interacts with EPO receptor and is responsible for the cellular responses. EPO is expressed in many cancers, including breast cancer, renal cancer, gastric cancer, hepatocellular carcinoma and central nervous system tumors. In addition, it is a hypoxia responsive cytokine and a pro-angiogenic factor. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. It can protect from brain damages due to ischemia and enhances memory as well as cognitive ability in humans suffering from vascular dementia.
Physikalische Form
Lyophilized from a PBS solution.
Angaben zur Herstellung
Centrifuge the vial prior to opening.
Rekonstituierung
Reconstitute in sterile PBS containing 0.1% endotoxin-free, recombinant human serum albumin.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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