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D4902

Dexamethason

powder, BioReagent, suitable for cell culture, ≥97%

Dexamethasone

Synonym(e):

(11β,16α)-9-Fluor-11,17,21-trihydroxy-16-methylpregna-1,4-dien-3,20-dion, 9α-Fluor-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadien-3,20-dion, 9α-Fluor-16α-methylprednisolon, Prednisolon F

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Ihnen/SKUVerfügbarkeitPreis
25 mg
Warenkorb auf Verfügbarkeit prüfen
€ 36,90
100 mg
Warenkorb auf Verfügbarkeit prüfen
€ 103,00
500 mg
Warenkorb auf Verfügbarkeit prüfen
€ 415,00
1 g
Warenkorb auf Verfügbarkeit prüfen
€ 621,00

Über diesen Artikel

Empirische Formel (Hill-System):
C22H29FO5
CAS-Nummer:
50-02-2
Molekulargewicht:
392.46
UNSPSC Code:
12352209
NACRES:
NA.75
PubChem Substance ID:
24893906
EC Number:
200-003-9
Beilstein/REAXYS Number:
2066651
MDL number:
MFCD00064136
Biological source:
synthetic
Form:
powder
Assay:
≥97%

€ 36,90

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Unterstützung erhalten

biological source

synthetic

Quality Segment

200

product line

BioReagent

assay

≥97%

form

powder

potency

4-500 ng/mL

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

mp

262-264 °C (lit.)

solubility

methanol: 25 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChI key

UREBDLICKHMUKA-CXSFZGCWSA-N

Gene Information

human ... ABCB1(5243), CYP3A4(1576), IL4(3565), IL5(3567), NR3C1(2908)
mouse ... Abcb1a(18671), Abcb1b(18669), Ifng(15978), Nos2(18126), Ptgs2(19225), Tnf(21926)
rat ... Ar(24208), Nr3c1(24413), Tnf(24835)

Application

Dexamethason wird in Studien über Apoptose, Zellsignalwege, Zelldifferenzierung[1] und Genexprimierung verwendet.

Biochem/physiol Actions

Glucocorticoid entzündungshemmendes Mittel
Glucocorticoid entzündungshemmendes Mittel. Reguliert T-Zell-Überleben, Wachstum und Differenzierung. Hemmt die Induktion von Stickstoffmonoxid-Synthase.
Schlechte Metabolisierung im Körper, hat eine hohe Affinität und Bioverfügbarkeit.

Packaging

Bodenlose Glasflasche. Der Inhalt befindet sich innerhalb des eingeschobenen Schmelzkegels.

Physical form

Pulver 2 - 8 °C; in Arbeitsaliquote aufgeteilt einfrieren, wiederholtes Einfrieren/Auftauen ist zu vermeiden

Preparation Note

Für die Herstellung von 20 μg/ml Stammlösung 1 ml absolutes Ethanol pro mg Produkt zugeben; zum Auflösen sanft schwenken. 49 ml steriles Medium pro ml hinzugefügtes Ethanol unter Mischen zugeben, um eine Endkonzentration von 20 μg/ml zu erhalten.

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Dieser Artikel
D1756D918446165
Dexamethason powder, BioReagent, suitable for cell culture, ≥97%

Sigma-Aldrich

D4902

Dexamethason

Dexamethason ≥98% (HPLC), powder

Sigma-Aldrich

D1756

Dexamethason

Dexamethason meets USP testing specifications

Sigma-Aldrich

D9184

Dexamethason

Dexamethason VETRANAL®, analytical standard

Supelco

46165

Dexamethason

biological source

synthetic

biological source

-

biological source

synthetic (organic)

biological source

-

assay

≥97%

assay

≥98% (HPLC)

assay

97.0-102.0%

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

product line

BioReagent

product line

-

product line

-

product line

VETRANAL®

technique(s)

cell culture | mammalian: suitable, single cell analysis: suitable

technique(s)

-

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

form

powder

form

powder

form

solid

form

-

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360FD

Hazard Classifications

Repr. 1B

Lagerklasse

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number

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Questions

1–10 of 20 Questions  

  1. Dear Customer support, Is this product  Dexamethasone, cat #D4902  suitable for in vivo use (mice treatment)?

    1 answer

    1. While we do not conduct in-house testing on these DMSO products in animals, there are numerous research papers available online documenting the utilization of this compound in animal studies. These papers serve as valuable resources for understanding the compound's effects and potential applications in various animal models:

      eNeuro. 2016 Mar-Apr; 3(2): ENEURO.0133-15.2016.
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819286/
      Mice were injected with carprofen (5 mg/kg, s.c.; catalog #024751, Butler Schein Animal Health) and dexamethasone (40 mg/kg, i.m.; catalog #D4902, Sigma-Aldrich) prior to surgery.

      https://www.google.com/search?q=D4902+mg%2Fkg+mice&rlz=1C1GCEA_enUS976US976&oq=D4902+mg%2Fkg+mice&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRigATIHCAIQIRigATIHCAMQIRigATIHCAQQIRigATIHCAUQIRigAdIBCDg3ODJqMGo3qAIAsAIA&sourceid=chrome&ie=UTF-8&sei=VudraPqaJO6t5NoPvZyokQw

      Helpful?

  2. Two questions: 1. How to store 1mg/ml solution and how stable? 2. Is it advisable to filter working solution 20ug/ml with 0.22 um prior to use?

    1 answer

    1. This product is stable for approximately 5 years in powder form with the vial unopened. It is guaranteed for 1 year from the date of shipment. The stability upon reconstitution has not been determined. However, for a similar product, it is recommended to aliquot and freeze at -20°C after reconstitution. Stock solutions are stable for up to 2 months at -20°C and should be protected from light. Degradation occurs gradually and depends on exposure frequency and intensity. Discolored, cloudy, or particulate-containing solutions should be discarded. Solutions can be sterile filtered using a 0.22 µm membrane, as the powders are not sterile.

      Helpful?

  3. Hello,  I prepared a solution of Dexamethasone in DMSO and PBS for IP injection in mice for 20 days daily. Is it okay to store the solution at 4°C?

    1 answer

    1. Dexamethasone solutions in DMSO are stable for at least 30 days when stored at 4 °C and protected from light. Do not dilute to working concentrations in an aqueous buffer or medium until ready to use.

      Helpful?

  4. Can I store D4902 at -80°C? If I store it at -80°C instead of -20°C, can I use it stably for more than 2 months?

    1 answer

    1. Long-term solution stability studies have not been performed on this material. The impact of stability at -80°C has not been determined. However, an analytical standard available at 1 mg/mL in methanol, as product D-085, has a shelf life of 4 years when stored at -20°C. In addition, therapeutic preparations of Dexamethasone 3.3 mg/mL for injection manufactured by Hospira, list a shelf life of 24 months at -20°C. This product, in solution, may demonstrate similar stability.

      Helpful?

  5. What is the solubility of D4902 (Dexamethasone) in DMSO and ethanol? Additionally, how should stock solutions be stored?

    1 answer

    1. The solubility of D4902 (Dexamethasone) in ethanol is 25 mg/ml and DMSO is 25 mg/ml. Dexamethasone is insoluble in water. Stock solutions are stable for up to 2 months at -20°C.

      Helpful?

  6. IF Dexamethasone solutions forgrt to protected from light, what will happen in these solutions?

    1 answer

    1. Prepared solutions of Dexamethasone should be protected from light. Degradation occurs gradually and is dependent on the frequency and intensity of exposure. Solutions that appear discolored, cloudy, or contain particulates should be discarded. Unfortunately, there is not way to determine the degree of decomposition.

      Helpful?

  7. I read that the dexamethasone is packaged in a bottomless glass bottle, in an inserted fused cone. Is this cone sealed with a rubber lid to be able to safely open the bottle and dissolve all contents before fully opening the bottle?

    1 answer

    1. Please see the attached images of the vial and cap used to package this product. The cap is a screw-type and does not include a septum. Threading secures the inner cone to the outer vial.

      Helpful?

  8. what are different between D4902 and D1756? and if the same the both, why D4902 is descriptive about 'suitable for cell culture'?

    1 answer

    1. Product D4902 and D1756 are identical compounds, but are tested differently. Product D4902 is tested specifically for suitability in cell culture applications, while the D1756 has a slightly higher minimum purity specification. Please see the sample Certificate of Analysis to view the testing and specifications for each product:

      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/D1756-BULKBCCK0031.pdf
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COFA/Q14/D4902-BULKBCCJ0003.pdf

      Helpful?

  9. Are there any references for D2915?

    1 answer

    1. Please check the following offerings for Certified Reference standards for Dexamethasone:

      https://www.sigmaaldrich.com/product/sial/d0700000
      https://www.sigmaaldrich.com/product/sial/phr1526
      https://www.sigmaaldrich.com/product/usp/1176007

      Helpful?

  10. Can I use Product D4902 as a local application (after preparation) to induce osteogenesis in a human clinical trial?

    1 answer

    1. This product is suitable for cell culture application and is intended for research use only. For more information on "Use of Products", please consult our Terms and Conditions https://www.sigmaaldrich.com/US/en/life-science/legal/terms-and-conditions#3

      Helpful?

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