SML1657

Gefitinib

≥98% (HPLC), powder, EGFR TK inhibitor

• Synonym(e): N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine, ZD1839
• Empirische Formel (Hill-System): C₂₂H₂₄ClFN₄O₃
• CAS-Nummer: 184475-35-2
• Molekulargewicht: 446.90
• MDL-Nummer: MFCD04307832
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825996
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Gefitinib, ≥98% (HPLC)
• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: COC(C=C(N=CN=C1NC2=CC(Cl)=C(F)C=C2)C1=C3)=C3OCCCN4CCOCC4
• InChI: 1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
• InChIKey: XGALLCVXEZPNRQ-UHFFFAOYSA-N
• Angaben zum Gen: human ... EGFR(1956)

Beschreibung

Anwendung

Gefitinib has been used :

• To study its effective use in endometrial cancer therapy[1]
• Cell proliferation, cell cycle and apoptosis assays[2]
• Cell viability assay and colony formation assay[3]

Biochem./physiol. Wirkung

Gefitinib is a selective epidermal growth factor receptor tyrosine kinase (EGFR TK) inhibitor. Gefitinib has antineoplastic activity, and has been approved for the treatment on non-small cell lung cancer (NSCLC).
Gefitinib has a higher affinity for ATP (adenosine triphosphate) binding site in the EGFR tyrosine kinase domain than ATP. Hence, gefitinib is known to inhibit the progression of endometrial cancer.[1]

Sicherheitshinweise

• Piktogramme: GHS08,GHS05,GHS07,GHS09
• Signalwort: Danger
• H-Sätze: H302,H315,H318,H351,H360Fd,H373,H410
• P-Sätze: P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Eye Dam. 1 - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable