SML1361

BRD73954

≥98% (HPLC)

• Synonym(e): N-Hydroxy-N′-phenethyl-isophthalamide, N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide, N1-Hydroxy-N3-phenethylisophthalamide
• Empirische Formel (Hill-System): C₁₆H₁₆N₂O₃
• CAS-Nummer: 1440209-96-0
• Molekulargewicht: 284.31
• MDL-Nummer: MFCD26383435
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329825816
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to light brown
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: ONC(C1=CC(C(NCCC2=CC=CC=C2)=O)=CC=C1)=O
• InChI: 1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20)
• InChIKey: FIHKWEQJEDRIFS-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

BRD73954 is the first discovered histone deacetylase 6/8 dual inhibitor. BRD73954 has an IC₅₀ of 36 nM for the class IIb HDAC6 and 120 nM for the class I HDAC8 with IC₄₅₀′s ranging from 9 μM to greater than 33 μM for other HDACs.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable