S7821

Sulfadoxin

≥95% (TLC)

• Synonym(e): 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)-benzolsulfonamid
• Empirische Formel (Hill-System): C₁₂H₁₄N₄O₄S
• CAS-Nummer: 2447-57-6
• Molekulargewicht: 310.33
• Beilstein: 625453
• EG-Nummer: 219-504-9
• MDL-Nummer: MFCD00792890
• UNSPSC-Code: 51101500
• PubChem Substanz-ID: 24899765
• NACRES: NA.85

Eigenschaften

• Assay: ≥95% (TLC)
• Form: powder
• Farbe: white
• Löslichkeit: ethanol: NH₄OH (9:1): soluble 20 mg/mL
• Wirkungsspektrum von Antibiotika: parasites
• Wirkungsweise: enzyme | inhibits
• SMILES String: COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC
• InChI: 1S/C12H14N4O4S/c1-19-10-11(14-7-15-12(10)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
• InChIKey: PJSFRIWCGOHTNF-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: sulfonamide

Anwendung

Sulfadoxine is a sulfonamide antibiotic used in combination with pyrimethamine for the treatment or prevention of malaria. It is also used to treat various infections in livestock. Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in patients where chloroquine resistance is suspected. It is used to study infections caused by Toxoplasma gondii and has been used to prevent infections after surgery during animal studies.

Biochem./physiol. Wirkung

Sulfadoxine is a sulfonamide antibacterial that inhibits dihydropteroate synthase (DHPS), an enzyme that transforms 4-aminobenzoic acid (PABA) in the synthesis of dihydropteroic acid. This enzyme is also a component of the folate metabolic pathway and is upstream of dihydrofolate reductase (DHFR).

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids