This product is slightly soluble in water at < 1mg/mL. Other solvents include DMSO, DMF, and Acetone at approximately 50 mg/mL.
Fortfahren mit
S6256
Sulfamethazin
99.0-101.0% (on dried basis)
Synonym(e):
4,6-Dimethylsulfadiazin, 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)-benzolsulfonamid, Sulfadimethyldiazin, Sulfadimidin
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| Ihnen/SKU | Verfügbarkeit | Preis |
|---|---|---|
25 g | Warenkorb auf Verfügbarkeit prüfen | € 52,30 |
100 g | Warenkorb auf Verfügbarkeit prüfen | € 93,40 |
Über diesen Artikel
Empirische Formel (Hill-System):
C12H14N4O2S
CAS-Nummer:
Molekulargewicht:
278.33
UNSPSC Code:
51284910
NACRES:
NA.85
PubChem Substance ID:
EC Number:
200-346-4
Beilstein/REAXYS Number:
261304
MDL number:
Technischer Dienst
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Unterstützung erhaltenQuality Segment
assay
99.0-101.0% (on dried basis)
form
powder or crystals
storage condition
(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
color
white to off-white
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
InChI
1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
InChI key
ASWVTGNCAZCNNR-UHFFFAOYSA-N
General description
Chemical structure: sulfonamide
Application
Biochem/physiol Actions
Ein antimikrobieller Schwefelwirkstoff. Induziert die CYP3A4-Expression und wird acetyliert durch N-Acetyltransferase. Weist geschlechtsabhängige Pharmakokinetik auf, metabolisiert durch die maskuline Isofrom CYP2C11.
Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
Packaging
25G,100G
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
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Dieser Artikel | |||
|---|---|---|---|
| description 99.0-101.0% (on dried basis) | description pharmaceutical secondary standard, certified reference material | description European Pharmacopoeia (EP) Reference Standard | description European Pharmacopoeia (EP) Reference Standard |
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| form powder or crystals | form - | form - | form - |
| assay 99.0-101.0% (on dried basis) | assay - | assay - | assay - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
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Lagerklasse
11 - Combustible Solids
ppe
Eyeshields, Gloves, type N95 (US)
signalword
Warning
hcodes
Hazard Classifications
Skin Irrit. 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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Is Sulfamethazine (Product code: S6256) soluble in water of in any specific solvent. Please suggest.
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