S6256

Sulfamethazin

99.0-101.0% (on dried basis)

• Synonym(e): 4,6-Dimethylsulfadiazin, 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)-benzolsulfonamid, Sulfadimethyldiazin, Sulfadimidin
• Empirische Formel (Hill-System): C₁₂H₁₄N₄O₂S
• CAS-Nummer: 57-68-1
• Molekulargewicht: 278.33
• Beilstein: 261304
• EG-Nummer: 200-346-4
• MDL-Nummer: MFCD00006066
• UNSPSC-Code: 51284910
• PubChem Substanz-ID: 24899686
• NACRES: NA.85

Eigenschaften

• Qualitätsniveau: 200
• Assay: 99.0-101.0% (on dried basis)
• Form: powder or crystals
• Lagerbedingungen: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• Farbe: white to off-white
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Wirkungsweise: DNA synthesis | interferes; enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1
• InChI: 1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
• InChIKey: ASWVTGNCAZCNNR-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: sulfonamide

Anwendung

Sulfamethazine is an antibiotic used to treat bronchitis, prostatitis and urinary tract infections[1]. It is used in disposition and depletion kinetic studies[2][3]. It is used to develop detection techniques for quantification in fluids such as cows′ milk, honey and swine urine[4].

Biochem./physiol. Wirkung

Ein antimikrobieller Schwefelwirkstoff. Induziert die CYP3A4-Expression und wird acetyliert durch N-Acetyltransferase. Weist geschlechtsabhängige Pharmakokinetik auf, metabolisiert durch die maskuline Isofrom CYP2C11.

Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.

Verpackung

25G,100G

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)