S7395

Spiperone

solid

• Synonym(e): 8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, R 5147, Spiroperidol
• Empirische Formel (Hill-System): C₂₃H₂₆FN₃O₂
• CAS-Nummer: 749-02-0
• Molekulargewicht: 395.47
• NACRES: NA.77
• PubChem Substance ID: 24277908
• UNSPSC Code: 12352200
• EC Number: 212-024-0
• MDL number: MFCD00055099
• Form: solid

Eigenschaften

• form: solid
• Quality Segment: 200
• color: light yellow
• solubility: H₂O: slightly soluble 0.2 mg/mL, 0.1 M HCl: slightly soluble 0.3 mg/mL, ethanol: 1.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL
• SMILES string: Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4
• InChI: 1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
• InChI key: DKGZKTPJOSAWFA-UHFFFAOYSA-N
• Gene Information: human ... ADRA1B(147), DRD2(1813), DRD3(1814), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356) ; rat ... Adra1a(29412), Adra1b(24173), Adra1d(29413), Adra2a(25083), Drd1a(24316), Drd2(24318), Drd3(29238), Htr1a(24473), Htr2a(29595), Htr2c(25187), Htr7(65032) ;

Beschreibung

General description

Spiperone is a butyrophenone antipsychotic agent. It induces calcium-dependent chloride secretion in the airway and functions as a potential therapeutic target for cystic fibrosis.

Application

Spiperone has been used to block the actions of 5-hydroxytryptamine (5-HT) receptor. It also has been used to study its anti tumor effects in glioblastoma (GBM) cell lines.

Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.⁶

Biochem/physiol Actions

Selective D₂ dopamine receptor antagonist; α_1B-adrenoceptor antagonist; mixed 5-HT_2A/5-HT₁ serotonin receptor antagonist; antipsychotic.

Preparation Note

Solutions may be stored for 1-2 days at 4 °C.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• Gefahrencodes: H302,H361
• Sicherheitshinweise: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Lagerklasse: 11 - Combustible Solids
• Was ist los?: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• PSA (Persönliche Schutzausrüstung): Eyeshields, Gloves, type P3 (EN 143) respirator cartridges