S7395

Spiperone

solid

• Synonym(e): 8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one, R 5147, Spiroperidol
• Empirische Formel (Hill-System): C₂₃H₂₆FN₃O₂
• CAS-Nummer: 749-02-0
• Molekulargewicht: 395.47
• EG-Nummer: 212-024-0
• MDL-Nummer: MFCD00055099
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277908
• NACRES: NA.77

Eigenschaften

• Form: solid
• Qualitätsniveau: 200
• Farbe: light yellow
• Löslichkeit: H₂O: slightly soluble 0.2 mg/mL; 0.1 M HCl: slightly soluble 0.3 mg/mL; ethanol: 1.5 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL
• SMILES String: Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4
• InChI: 1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
• InChIKey: DKGZKTPJOSAWFA-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADRA1B(147) , DRD2(1813) , DRD3(1814) , HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) ; rat ... Adra1a(29412) , Adra1b(24173) , Adra1d(29413) , Adra2a(25083) , Drd1a(24316) , Drd2(24318) , Drd3(29238) , Htr1a(24473) , Htr2a(29595) , Htr2c(25187) , Htr7(65032)

Beschreibung

Allgemeine Beschreibung

Spiperone is a butyrophenone antipsychotic agent.[1] It induces calcium-dependent chloride secretion in the airway and functions as a potential therapeutic target for cystic fibrosis.[2]

Anwendung

Spiperone has been used to block the actions of 5-hydroxytryptamine (5-HT) receptor.[3][4] It also has been used to study its anti tumor effects in glioblastoma (GBM) cell lines.[5]

Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.⁶

Biochem./physiol. Wirkung

Selective D₂ dopamine receptor antagonist; α_1B-adrenoceptor antagonist; mixed 5-HT_2A/5-HT₁ serotonin receptor antagonist; antipsychotic.

Rekonstituierung

Solutions may be stored for 1-2 days at 4 °C.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302,H361
• P-Sätze: P201 - P301 + P312 + P330 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Repr. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges