S7771

(S)-(−)-Sulpirid

≥98% (titration)

• Synonym(e): (S)-(−)-5-(Aminosulfonyl)-N-(1-ethyl-2-pyrrolidinylmethyl)-2-methoxybenzamid, Levosulpirid
• Empirische Formel (Hill-System): C₁₅H₂₃N₃O₄S
• CAS-Nummer: 23672-07-3
• Molekulargewicht: 341.43
• NACRES: NA.77
• PubChem Substance ID: 24278709
• UNSPSC Code: 12352200
• MDL number: MFCD00055220
• Assay: ≥98% (titration)

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (titration)
• mp: 183-186 °C (lit.)
• originator: Sanofi Aventis
• storage temp.: 2-8°C
• SMILES string: CCN1CCC[C@H]1CNC(=O)c2cc(ccc2OC)S(N)(=O)=O
• InChI: 1S/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/t11-/m0/s1
• InChI key: BGRJTUBHPOOWDU-NSHDSACASA-N
• Gene Information: human ... DRD2(1813), DRD3(1814) ; rat ... Adra1a(29412), Drd2(24318), Drd3(29238), Htr1a(24473), Htr2a(29595)

Beschreibung

Application

(S)-(−)-Sulpiride was used to study the effect of dopamine D₂ receptor function on activation of KCNQ potassium channels¹⁰ and on depression-like behavior in ovariectomized female rats.¹¹

Biochem/physiol Actions

D₂ Dopamin-Rezeptor-Antagonist; antipsychotisch

(S)-(−)-Sulpiride or Levosulpiride blocks the inhibitory enteric D₂ receptors (neuronal and muscular). It has prokinetic activity and is effective in the treatment of functional dyspepsia and gastroparesis in insulin-dependent diabetes mellitus patients.^7,8 Since dopamine controls human sexual function, (S)-(−)-Sulpiride is reportedly effective in treatment of erectile dysfunctions.⁹

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable