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S4139
Spermidin
BioReagent, suitable for cell culture
Synonym(e):
1,8-Diamino-4-azaoctan, N-(3-Aminopropyl)-1,4-diaminobutan
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About This Item
Lineare Formel:
NH2(CH2)3NH(CH2)4NH2
CAS-Nummer:
Molekulargewicht:
145.25
Beilstein:
1698591
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
Empfohlene Produkte
Produktlinie
BioReagent
Assay
≥98% (GC)
Form
solid
Methode(n)
cell culture | mammalian: suitable
Farbe
clear colorless to light yellow-white
Brechungsindex
n20/D 1.479 (lit.)
Dichte
0.925 g/mL at 25 °C (lit.)
Lagertemp.
2-8°C
SMILES String
NCCCCNCCCN
InChI
1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
InChIKey
ATHGHQPFGPMSJY-UHFFFAOYSA-N
Angaben zum Gen
rat ... Ppm1a(24666)
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Biochem./physiol. Wirkung
Hemmt die neuronale Stickoxidsynthase (nNOS). Bindet und fällt DNA aus; kann zur Aufreinigung von DNA-Bindungsproteinen verwendet werden. Stimuliert die T4-Polynukleotidkinaseaktivität.
Hemmt die neuronale Stickoxidsynthase (nNOS). Bindet und fällt DNA aus; stimuliert die T4-Polynukleotidkinaseaktivität.
Spermidine together with putrescine and spermine compose a family of biogenic polyamines (polycations) that are required for the survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycan, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols. Spermidine Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.
Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.
Spermidine is biogenic polyamine formed from putrescine, a precursor of spermine. It was first detected in human sperm, but occurs widely in nature. It is essential in both normal and neoplastic tissue growth. Spermidine has a role in cell growth processes and the formation and interconversion of spermidine in mammalian cells has been reported. It has been studied in the regulation of tRNA methyltransferase activity and stimulates T4 polynucleotide kinase activity.
Vorsicht
Für eine sterile Lösung soll die Lösung steril-filtriert und nicht autoklaviert werden. Spermidin deaminiert mit der Zeit; Lösungen tiefgekühlt lagern. Regelmässig frische Lösungen zubereiten.
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Produkt-Nr.
Beschreibung
Preisangaben
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Skin Corr. 1B
Lagerklassenschlüssel
8A - Combustible corrosive hazardous materials
WGK
WGK 3
Flammpunkt (°F)
233.6 °F - closed cup
Flammpunkt (°C)
112 °C - closed cup
Persönliche Schutzausrüstung
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
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The biochemistry and biological function of the naturally occurring polyamines, putrescine, spermidine, and spermine, have been reviewed with special reference to animal organisms. These compounds are universally distributed in all living material. Their biosynthesis from ornithine and methionine is accurately
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