R108

Ro 41-0960

solid

• Synonym(e): 2′-Fluoro-3,4-dihydroxy-5-nitrobenzophenone
• Empirische Formel (Hill-System): C₁₃H₈FNO₅
• CAS-Nummer: 125628-97-9
• Molekulargewicht: 277.20
• MDL-Nummer: MFCD00078597
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278193
• NACRES: NA.77

Eigenschaften

• Form: solid
• Qualitätsniveau: 100
• Lagerbedingungen: protect from light
• Farbe: yellow
• Löslichkeit: H₂O: slightly soluble <0.7 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL; ethanol: soluble
• Lagertemp.: 2-8°C
• SMILES String: Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F
• InChI: 1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H
• InChIKey: RQPAUNZYTYHKHA-UHFFFAOYSA-N
• Angaben zum Gen: human ... COMT(1312)

Beschreibung

Anwendung

Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations [1] and 3T3-L1 adipocytes.[2] It has also been used as a catechol-O-methyl-transferase inhibitor to treat corpus striatum samples to test its effect on dopamine metabolism.[3]

Biochem./physiol. Wirkung

Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT).[4] It binds to the catalytic site and triggers the inhibition of the methylation property of COMT.[5] Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids.[4]

Leistungsmerkmale und Vorteile

This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Vorsicht

Store tightly sealed at 4 °C, protected from exposure to light.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)