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R5010

Resveratrol

≥99% (HPLC)

Synonym(e):

3,4′,5-Trihydroxy-trans-stilben, 5-[(1E)-2-(4-Hydroxyphenyl)-ethenyl]-1,3-dihydroxybenzol

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Größe/SKUVerfügbarkeitPreis
100 mg
Warenkorb auf Verfügbarkeit prüfen
€ 248,00
500 mg
Warenkorb auf Verfügbarkeit prüfen
€ 963,00

Über diesen Artikel

Empirische Formel (Hill-System):
C14H12O3
CAS-Nummer:
Molekulargewicht:
228.24
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:

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biological source

plant root (bushy knotweed)

Quality Segment

assay

≥99% (HPLC)

form

powder

solubility

acetone: 50 mg/mL, clear, faintly yellow

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

−20°C

SMILES string

Oc1ccc(cc1)\C=C\c2cc(O)cc(O)c2

InChI

1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+

InChI key

LUKBXSAWLPMMSZ-OWOJBTEDSA-N

Gene Information

Application

Selektiver Inhibitor von COX−1.
Resveratrol wurde eingesetzt:
  • in Einschlussexperimenten
  • zur Untersuchung der neuroprotektiven Wirkung auf retinalen neuronalen Zelltod durch diabetes-induzierte Aktivierung von Ca2+/Calmodulin-abhängige Proteinkinase II
  • als Standard bei der Bewertung des Stilbengehalts in Weinblättern mittels In-vivo-Fluorometrie

Biochem/physiol Actions

Resveratrol ist ein phenolisches Phytoalexin, das in der Traubenschale und anderen Pflanzen vorkommt. Es wirkt intrazellulär als Antioxidans und aktiviert Sirtuin-1 (SIRT1), eine Nicotinamid-Adenin-Dinukleotid-(NAD+)abhängige Histondeacetylase, die an der mitochondrialen Biogenese beteiligt ist und die Aktivität des Peroxisom-Proliferator-aktivierten Rezeptor-g-Co-Aktivators-1a (PGC-1a) und die FOXO- (Forkhead-Box-)Aktivität fördert. Die antidiabetische, neuroprotektive und antiadipogene Wirkung von Resveratrol kann durch SIRT1-Aktivierung herbeigeführt werden. Resveratrol hat eine antivirale Wirkung gegen Herpes simplex virus-1 (HSV1) und HSV2. Es zeigt auch antitumorale und phytoöstrogene biologische Wirkung. Resveratrol ist für die lebensverlängernde Wirkung bei vielen Arten durch Unterstützen verschiedener physiologischer Funktionen bekannt.

Preparation Note

Löslich in Ethanol, DMSO und Aceton. Nur sehr schwer in Wasser löslich (3 mg/100 mL).

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Dieser Artikel
Y00011947651134092
Resveratrol European Pharmacopoeia (EP) Reference Standard

Y0001194

Resveratrol

description

≥99% (HPLC)

description

European Pharmacopoeia (EP) Reference Standard

description

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

description

analytical standard

form

powder

form

-

form

-

form

-

assay

≥99% (HPLC)

assay

-

assay

-

assay

-

biological source

plant root (bushy knotweed)

biological source

-

biological source

-

biological source

-

Quality Level

200

Quality Level

-

Quality Level

300

Quality Level

100

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

application(s)

pharmaceutical (small molecule)

application(s)

food and beverages

application(s)

cleaning products
cosmetics
food and beverages
personal care

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C


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Lagerklasse

11 - Combustible Solids

flash_point_f

>392.0 °F - closed cup - (External MSDS)

flash_point_c

> 200.0 °C - closed cup - (External MSDS)

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

hcodes

Hazard Classifications

Aquatic Chronic 3



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Questions

1–10 of 11 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. Can a resveratrol solution turn red?

    1 answer
    1. Solubility is tested in acetone, resulting in a faint yellow color. In acidic conditions, resveratrol can appear more reddish. In neutral or alkaline conditions, resveratrol will appear yellowish or colorless. Oxidation of resveratrol may also change its color, potentially leading to a reddish hue. Resveratrol is highly oxidizable and reacts readily with reactive oxygen species.

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  4. What is the solubility limit in ethanol ?

    1 answer
    1. This product is tested for solubility in acetone at 50 mg/mL. It is soluble in ethanol at 50 mg/mL and in DMSO at 16 mg/mL.

      Helpful?

  5. does it expires? How long does powder last?

    1 answer
    1. This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one year warranty from the date of shipment. For more information you may access the "Product Dating Information" document under "ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS" at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.

      Helpful?

  6. 1- What is the iso-form (Cis or Trans) of the Resveratrol product R5010-500MG? 2- Do you have it emission spectra in 2-propanol and DMSO?

    1 answer
    1. As per the IUPAC name given, this product is a trans isoform. Unfortunately, emission spectra in 2-propanol and DMSO cannot be provided.

      Helpful?

  7. In what applications do researchers use Resveratrol, Product R5010?

    1 answer
    1. There are numerous applications for Resveratrol.  Several references indicate that it is used as a COX-1 inhibitor and a tumor repressor.

      Helpful?

  8. How do I dissolve Resveratrol, Product R5010?

    1 answer
    1. We test the solubility in ethanol at a concentration of 50 mg/mL.  It is also soluble at 16 mg/mL in DMSO (with sonication). It is practically insoluble in water.

      Helpful?

  9. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  10. How do I store Resveratrol, Product R5010, once in solution?

    1 answer
    1. A 5 mM solution of R5010 in ethanol has been found to be stable for 12 weeks when stored at 2-8°C and protected from light.Given a molecular weight of 228.24, a 5 mM solution is approximately 1.1 mg/mL.Reference: D.M. Goldberg, et al., J. Chrom. A, 708, 89-98 (1995).

      Helpful?

1–10 of 11 Questions  

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