N156

Naltriben methanesulfonate hydrate

≥98% (HPLC), solid

• Synonym(e): NTB hydrate
• Empirische Formel (Hill-System): C₂₆H₂₅NO₄ · CH₄O₃S · xH₂O
• CAS-Nummer: 1309441-44-8
• Molekulargewicht: 511.59 (anhydrous basis)
• MDL-Nummer: MFCD11046015
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278045
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Arzneimittelkontrolle: regulated under CDSA - not available from Sigma-Aldrich Canada
• Farbe: off-white
• Löslichkeit: DMSO: 14 mg/mL at ~60 °C
• Lagertemp.: −20°C
• SMILES String: O.CS(O)(=O)=O.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)c6oc7ccccc7c6C[C@@]35O)CC8CC8
• InChI: 1S/C26H25NO4.CH4O3S.H2O/c28-18-8-7-15-11-20-26(29)12-17-16-3-1-2-4-19(16)30-22(17)24-25(26,21(15)23(18)31-24)9-10-27(20)13-14-5-6-14;1-5(2,3)4;/h1-4,7-8,14,20,24,28-29H,5-6,9-13H2;1H3,(H,2,3,4);1H2/t20-,24+,25+,26-;;/m1../s1
• InChIKey: VAGWKZSGWSRENH-HIAJFTJMSA-N

Beschreibung

Anwendung

Naltriben methanesulfonate hydrate has been used in the assessment of parasite growth and evaluation of growth inhibition. It has also been used to understand the action of deltorphin-II in exhibiting its antimalarial effect.

Biochem./physiol. Wirkung

Naltriben methanesulfonate is a highly selective δ2 opioid receptor antagonist. The relative ability of the delta antagonists benzylidenenaltrexone and naltriben to inhibit DPDPE-stimulated [35S]GTPgammaS binding suggests that the opioid receptor is of the delta-2 subtype. Ligand binding assays demonstrates biphasic binding of the antagonist to the single receptor type. [35S]GTPgammaS binding is also stimulated by [D-Ser2,Leu5,Thr6]enkephalin > deltorphin II = DPDPE = etorphine > levallorphan = diprenorphine = nalorphine = naltrindole.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)