I9532

Icilin

≥97% (HPLC), solid

• Synonym(e): 1-(2-Hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetra­hydro­pyrimidin-2-one, AG-3-5
• Empirische Formel (Hill-System): C₁₆H₁₃N₃O₄
• CAS-Nummer: 36945-98-9
• Molekulargewicht: 311.29
• MDL-Nummer: MFCD01689072
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277906
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥97% (HPLC)
• Form: solid
• Farbe: yellow
• Löslichkeit: DMSO: 15 mg/mL
• SMILES String: Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O
• InChI: 1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21)
• InChIKey: RCEFMOGVOYEGJN-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Icilin is a synthetic cooling agent and modulates human transient receptor potential cation channel (TRPA1). Icilin inhibits transient receptor potential cation channel subfamily M member 8 (TRPM8)[1] and modulates calcium release.[2] Icilin also suppresses transient receptor potential vanilloid subtype 3 (TRPV3).[3]

Anwendung

Icilin has been used as cooling agent in anterior ventromedial preoptic area (VMPO) neurons.[4]

Biochem./physiol. Wirkung

Icilin is a potent agonist at the CMR1 cold- and menthol-sensitive receptor.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves