M2525

Mianserin -hydrochlorid

• Synonym(e): 1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepin -hydrochlorid
• Empirische Formel (Hill-System): C₁₈H₂₀N₂ · HCl
• CAS-Nummer: 21535-47-7
• Molekulargewicht: 300.83
• EG-Nummer: 244-426-7
• MDL-Nummer: MFCD00055072
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278125
• NACRES: NA.77

Eigenschaften

• Löslichkeit: H₂O: 3.4 mg/mL; ethanol: 5.6 mg/mL
• Ersteller: Organon
• Lagertemp.: 2-8°C
• SMILES String: Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24
• InChI: 1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
• InChIKey: YNPFMWCWRVTGKJ-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

Beschreibung

Anwendung

Mianserin hydrochloride has been used:

• as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)
• as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression
• as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation

Biochem./physiol. Wirkung

Antidepressivum; Antagonist/inverser Agonist an 5-HT_2-Serotonin-Rezeptoren, blockiert auch den H₁-Histamin-Rezeptor und den α₂ Adrenozeptor.

Mianserin is a tetracyclic compound with sedative property. It lacks anticholinergic activity and is not effective on serotoninergic mechanisms. Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.

Leistungsmerkmale und Vorteile

This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Angaben zur Herstellung

Solutions may be stored for several days at 4°C.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves