I7379

Imipramin -hydrochlorid

≥99% (TLC), powder, selective serotonin reuptake inhibitor

• Synonym(e): 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepin-5-propanamin -hydrochlorid, 5-[3-(Dimethylamino)-propyl]-10,11-dihydro-5H-dibenz[b,f]azepin -hydrochlorid
• Empirische Formel (Hill-System): C₁₉H₂₄N₂ · HCl
• CAS-Nummer: 113-52-0
• Molekulargewicht: 316.87
• NACRES: NA.77
• PubChem Substance ID: 24278097
• UNSPSC Code: 12352116
• EC Number: 204-030-7
• MDL number: MFCD00012669
• Assay: ≥99% (TLC)
• Form: powder

Eigenschaften

• Produktname: Imipramin -hydrochlorid, ≥99% (TLC)
• Quality Segment: 200
• assay: ≥99% (TLC)
• form: powder
• color: white
• solubility: H₂O: 50 mg/mL
• originator: Novartis
• SMILES string: Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
• InChI: 1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
• InChI key: XZZXIYZZBJDEEP-UHFFFAOYSA-N
• Gene Information: human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A2(6530), SLC6A4(6532)

Beschreibung

General description

Imipramine is a tricyclic antidepressant. It has a half-life of 6 to 20 hours. Imipramine is made up of a tricyclic nucleus, that consists of two phenyl rings and a central cycloheptadien ring.

Application

Imipramine hydrochloride has been used:

• as a non- selective serotonin reuptake inhibitor (SSRI) tricyclic anti-depressant (DD-IMI) to treat animals
• to investigate its interaction with insulin in aqueous solution
• to abolish the ability of internalized lipoproteins to stimulate cholesteryl esterification

Biochem/physiol Actions

Tricyclisches Antidepressivum; hemmt die Serotonin- und Noradrenalin-Transporter mit K_is von 7.7 nM bzw. 67 nM. Hat wenig Einfluss auf Dopamin-Transporter (K_i = 25 μM).

Tricyclisches Antidepressivum; hemmt die Serotonin- und Noradrenalin-Transporter, hat wenig Einfluss auf Dopamin-Transporter.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters and Chloride Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H300
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Lagerklasse: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable