I2765

Ibotenic acid

~95% (TLC), solid, neurotoxin

• Synonym(e): α-Amino-3-hydroxy-5-isoxazoleacetic acid
• Empirische Formel (Hill-System): C₅H₆N₂O₄
• CAS-Nummer: 2552-55-8
• Molekulargewicht: 158.11
• MDL-Nummer: MFCD00069294
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 24277994
• NACRES: NA.32

Eigenschaften

• Produktbezeichnung: Ibotenic acid, ~95%, solid
• Assay: ~95%
• Qualitätsniveau: 100
• Form: solid
• Farbe: white
• Löslichkeit: H₂O: 1 mg/mL, clear, colorless (with sonication); 0.1 M NaOH: 10.7 mg/mL; 0.1 M HCl: 4.7 mg/mL
• SMILES String: NC(C(O)=O)C1=CC(=O)NO1
• InChI: 1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
• InChIKey: IRJCBFDCFXCWGO-UHFFFAOYSA-N
• Angaben zum Gen: rat ... Grm1(24414) , Grm2(24415)

Beschreibung

Anwendung

Ibotenic acid has been used as a neurontoxin in rats[1]. It has also been used in inducing a primary permanent lesion monkey cortex M1 neurons.[2]

Ibotenic acid has been used to perform surgery in adult male zebra finches (Taeniopygia guttata) to study reversing reinforcement-induced vocal changes.[3]

Biochem./physiol. Wirkung

Ibotenic acid is an analog of glutamate. It is involved in the excitation of cell bodies and destroys the thalamic reticular nucleus (NRT).[4] It induces high calcium influx leading to neuronal injury. Ibotenic acid is used to induce neurodegeneration due to its excitotoxic functionality.[5]

Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin.

Non-selective agonist with preference for NMDA glutamate receptors; neurotoxin; neuroexcitatory amino acid originally isolated from Amanita species.

Vorsicht

Hygroscopic

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P310 + P330
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges