Fortfahren mit
H130
R(+)-HA-966
solid
Synonym(e):
R(+)-3-Amino-1-hydroxy-2-pyrrolidinone
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| Packungsgröße | SKU | Verfügbarkeit | Preis |
|---|---|---|---|
| 5 mg | Warenkorb auf Verfügbarkeit prüfen | € 155,00 € 131,75 |
Über diesen Artikel
Empirische Formel (Hill-System):
C4H8N2O2
CAS-Nummer:
Molekulargewicht:
116.12
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352111
MDL number:
Form:
solid
Quality level:
€ 131,75
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Technischer Dienst
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Unterstützung erhaltenform
solid
Quality Level
optical activity
[α]22/D +103°, c = 1 in H2O(lit.)
color
white
solubility
H2O: soluble
SMILES string
N[C@@H]1CCN(O)C1=O
InChI
1S/C4H8N2O2/c5-3-1-2-6(8)4(3)7/h3,8H,1-2,5H2/t3-/m1/s1
InChI key
HCKUBNLZMKAEIN-GSVOUGTGSA-N
Biochem/physiol Actions
Antagonist of the strychnine-insensitive glycine modulatory site associated with the NMDA receptor. More active enantiomer of (±)-HA-966.
Features and Benefits
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
1 of 1
Dieser Artikel | |||
|---|---|---|---|
| form solid | form solid | form solid | form solid |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: soluble | solubility H2O: 28 mg/mL | solubility H2O: 6 mg/mL, DMSO: soluble | solubility H2O: >5 mg/mL |
| color white | color white | color white to off-white | color white |
| optical activity [α]22/D +103°, c = 1 in H2O(lit.) | optical activity - | optical activity [α]22/D +15.14°, c = 0.52 in DMF(lit.) | optical activity [α]/D +32.1°, c = 1 in DMF(lit.) |
Lagerklasse
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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L Singh et al.
European journal of pharmacology, 186(1), 129-132 (1990-09-04)
Using a two-lever operant drug discrimination paradigm, rats have been trained to discriminate between the administration of saline and R-(+)-HA-966 (R-(+)-3-amino-1-hydroxypyrrolid-2-one, 30 mg/kg i.p.) an antagonist at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor/ion channel complex. Drug-appropriate responding
L Singh et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(1), 347-351 (1990-01-01)
The antagonist effect of (+/-)-3-amino-1-hydroxypyrrolid-2-one (HA-966) at the N-methyl-D-aspartate (NMDA) receptor occurs through a selective interaction with the glycine modulatory site within the receptor complex. When the enantiomers of (+/-)-HA-966 were resolved, the (R)-(+)-enantiomer was found to be a selective
L M Pullan et al.
Journal of neurochemistry, 55(4), 1346-1351 (1990-10-01)
HA-966 (1-hydroxy-3-aminopyrrolidone-2) is an antagonist at the glycine allosteric site of the N-methyl-D-aspartate receptor ionophore complex. Unlike presently known glycine antagonists, HA-966 is chiral. We report stereoselectivity for the (R)-enantiomer at the glycine antagonist site. In [3H]glycine binding, the (R)-enantiomer
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H130-5MG | 04061833620687 |