M104

(±)-Muscarine chloride hydrate

≥98% (HPLC)

• Synonym(e): Tetrahydro-4-hydroxy-N,N,N,5-tetramethyl-2-furanmethanammonium chloride hydrate
• Empirische Formel (Hill-System): C₉H₂₀ClNO₂ · xH₂O
• CAS-Nummer: 2936-25-6
• Molekulargewicht: 209.71 (anhydrous basis)
• NACRES: NA.77
• PubChem Substance ID: 24278578
• UNSPSC Code: 12352200
• MDL number: MFCD00055067
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 100
• Storage condition: desiccated

Eigenschaften

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white
• solubility: deionized water: ≥20 mg/mL
• storage temp.: room temp
• SMILES string: [Cl-].CC1OC(CC1O)C[N+](C)(C)C
• InChI: 1S/C9H20NO2.ClH/c1-7-9(11)5-8(12-7)6-10(2,3)4;/h7-9,11H,5-6H2,1-4H3;1H/q+1;/p-1
• InChI key: WUFRNEJYZWHXLC-UHFFFAOYSA-M
• Gene Information: human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Beschreibung

Application

(±)-Muscarine chloride hydrate may be used:

• as an acetylcholine receptor agonist in neuronal precursor cell lines PC 12 cells
• as toxin test compound for paper spray mass spectrometry (PSMS) optimization experiments[1]
• as a component of quality control(QC) in hydrophilic interaction liquid chromatography-high resolution tandem mass spectrometry (HILIC-HRMS/MS) analysis of human urine samples[2]

Biochem/physiol Actions

Muscarine is a potent agonist than acetylcholine and is not susceptible to degradation by cholinesterases.[3] Muscarine administration results in muscle spasm especially in gut, bronchus and uterus.[3]

Muscarinic acetylcholine receptor agonist; originally isolated from Amanita muscaria.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319
• pcodes: P264 - P270 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves