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Lectin coated MgO nanoparticle: its toxicity, antileishmanial activity, and macrophage activation.

Lectin coated MgO nanoparticle: its toxicity, antileishmanial activity, and macrophage activation.

Drug and chemical toxicology (2014-01-08)

Ali Jebali, Seyedhossein Hekmatimoghaddam, Bahram Kazemi, Azra Allaveisie, Alireza Masoudi, Karim Daliri, Najme Sedighi, Javad Ranjbari

摘要

The purpose of this research was to evaluate toxicity of uncoated magnesium oxide nanoparticles (MgO NPs), MgO NPs coated with Peanut agglutinin (PNA) lectin, and PNA alone on the promastigotes of Leishmania major (L. major) and macrophages of BALB/c mice. On the other hand, antileishmanial property of uncoated MgO NPs, lectin coated MgO NPs, and PNA lectin alone was evaluated, and also macrophage activation was investigated after treatment with these materials by measurement of nitrite, H2O2, and some interleukins. This study showed that PNA lectin and lectin coated MgO NPs had approximately no toxicity on L. major and macrophages, but some toxic effects were observed for uncoated MgO NPs, especially at concentration of 500 µg/mL. Interestingly, lectin coated MgO NPs had the highest antileishmanial activity and macrophage activation, compared with uncoated MgO NPs and PNA lectin.

材料

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甲醇, suitable for HPLC, ≥99.9%

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2-丙醇, ACS reagent, ≥99.5%

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甲醇, ACS reagent, ≥99.8%

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过氧化氢溶液, contains inhibitor, 30 wt. % in H₂O, ACS reagent

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甲醇, suitable for HPLC, gradient grade, ≥99.9%

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甲醇, HPLC Plus, ≥99.9%

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过氧化氢溶液, 30 % (w/w) in H₂O, contains stabilizer

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2-丙醇, HPLC Plus, for HPLC, GC, and residue analysis, 99.9%

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过氧化氢溶液, 50 wt. % in H₂O, stabilized

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