C6643

氯贝丁酯

liquid

• 同義詞: 氯贝特
• 經驗公式（希爾表示法）: C₁₂H₁₅ClO₃
• CAS號碼: 637-07-0
• 分子量：: 242.70
• Beilstein: 1913459
• EC號碼: 211-277-4
• MDL號碼: MFCD00000615
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278085
• NACRES: NA.77

屬性

• 形狀: liquid
• 顏色: clear colorless
• 密度: 1.14 g/mL at 25 °C (lit.)
• 起源: Wyeth
• 儲存溫度: 2-8°C
• SMILES 字串: CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1
• InChI: 1S/C12H15ClO3/c1-4-15-11(14)12(2,3)16-10-7-5-9(13)6-8-10/h5-8H,4H2,1-3H3
• InChI 密鑰: KNHUKKLJHYUCFP-UHFFFAOYSA-N
• 基因資訊: human ... PPARA(5465) ; mouse ... Ppara(19013)

描述

應用

Clofibrate has been used:

• as a quinolinate phosphoribosyltransferase (QPRT) agonist to study its effects on hepatitis C virus (HCV) infection[1]
• as peroxisome proliferated activated receptor (PPAR) agonist to study its effects on autophagy in rat liver cells[2]
• as a hepatotoxicant to study its effects on gene expression in primary rat hepatocytes[3]

生化／生理作用

Clofibrate is a peroxisome proliferated activated receptor α (PPARα) agonist.[4] It is a fibric acid derivative and has a therapeutic effect on hypertriglyceridemia and hyperlipoproteinemia type III. Clofibrate participates in lowering the very-low-density lipoprotein (VLDL) and cholesterol levels in hyperlipoproteinemia type III patients. It facilitates the decrease of total serum bilirubin concentration in Gilbert′s syndrome.[5]

特點和優勢

This compound is featured on the Nuclear Receptors (PPARs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

包裝

Bottomless glass bottle. Contents are inside inserted fused cone.

安全資訊

• 象形圖: GHS05,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H315,H318,H335
• 防範說明: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 235.4 °F - closed cup
• 閃點（°C）: 113 °C - closed cup
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter