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Merck
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重要文件

G9518

Sigma-Aldrich

吉非罗齐

同義詞:

2,2-二甲基-5-(2,5-二甲基苯氧基)戊酸, 2,2-二甲基-5-(2,5-二甲苯氧基)戊酸, 5-(2,5-二甲基苯氧基)-2,2-二甲基戊酸

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About This Item

經驗公式(希爾表示法):
C15H22O3
CAS號碼:
分子量::
250.33
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77
暫時無法取得訂價和供貨情況

形狀

powder

品質等級

SMILES 字串

Cc1ccc(C)c(OCCCC(C)(C)C(O)=O)c1

InChI

1S/C15H22O3/c1-11-6-7-12(2)13(10-11)18-9-5-8-15(3,4)14(16)17/h6-7,10H,5,8-9H2,1-4H3,(H,16,17)

InChI 密鑰

HEMJJKBWTPKOJG-UHFFFAOYSA-N

基因資訊

human ... PPARA(5465)

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一般說明

吉非罗齐是一种纤维酸衍生物和降血脂药。吉非罗齐可作为 PPARα(过氧化物酶体增殖物激活受体 α)的配体。[1][2]

應用

吉非罗齐已被用于研究其对酵母细胞周期进程的影响。[3]它已被用于研究贝特类药物对人细胞系中细胞增殖和基因表达的影响。[1]

生化/生理作用

吉非罗齐选择性增加载脂蛋白 A-I 水平。[4]在酵母细胞中,吉非罗齐的应用会延迟 DNA 复制的开始。[3]它被用作血脂异常的治疗药物。[1]

特點和優勢

这种化合物是ADME毒性研究的特色产品。点击此处发现更多特色ADME毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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存取文件庫

Katerina Cizkova et al.
Lipids in health and disease, 15(1), 164-164 (2016-09-24)
Fibrates are widely used hypolipidemic drugs, which serve as ligand of peroxisome proliferator-activated receptor α (PPARα). Recently, they have also been considered as potential anticancer agents. We studied effect of fibrates treatment on cell proliferation, expression of CYP2J2 and concomitant
Izabela Zakrocka et al.
Life (Basel, Switzerland), 13(11) (2023-11-25)
Kidney dysfunction significantly increases the cardiovascular risk, even in cases of minor functional declines. Hypertriglyceridemia is the most common lipid abnormality reported in patients with kidney disorders. PPAR-α (peroxisome proliferator-activated receptor-α) agonists called fibrates are the main agents used to
Benjamin Allcock et al.
Cells, 12(19) (2023-10-13)
It is widely recognised that cells respond to their microenvironment, which has implications for cell culture practices. Growth cues provided by 2D cell culture substrates are far removed from native 3D tissue structure in vivo. Geometry is one of many
A M Filppula et al.
Clinical pharmacology and therapeutics, 94(3), 383-393 (2013-05-10)
Cytochrome P450 (CYP) 3A4 is considered the most important enzyme in imatinib biotransformation. In a randomized, crossover study, 10 healthy subjects were administered gemfibrozil 600 mg or placebo twice daily for 6 days, and imatinib 200 mg on day 3, to study
Ana Maria Sierra Villar et al.
International journal of pharmaceutics, 431(1-2), 161-175 (2012-04-14)
Self-nanoemulsifying drug delivery systems of gemfibrozil were developed under Quality by Design approach for improvement of dissolution and oral absorption. Preliminary screening was performed to select proper components combination. Box-Behnken experimental design was employed as statistical tool to optimize the

文章

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

脂蛋白包裝膽固醇以便在血漿中運輸,對於人體中的脂質運輸和細胞功能是不可或缺的。

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for Lipid Signaling Research

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