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重要文件

N0258

Sigma-Aldrich

N-亚硝基二乙胺

ISOPAC®

同義詞:

二乙基亚硝胺

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About This Item

線性公式:
(C2H5)2NNO
CAS號碼:
分子量::
102.14
Beilstein:
1744991
EC號碼:
MDL號碼:
分類程式碼代碼:
12352116
PubChem物質ID:
NACRES:
NA.25
暫時無法取得訂價和供貨情況

形狀

liquid

bp

177 °C (lit.)

密度

0.95 g/mL (lit.)

SMILES 字串

CCN(CC)N=O

InChI

1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3

InChI 密鑰

WBNQDOYYEUMPFS-UHFFFAOYSA-N

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應用

N-亚硝基二乙胺(NDEA)已被用作肝致癌物/DNA损伤剂。[1][2]它已被用作气液色谱的校准标准品。[3]

生化/生理作用

N-亚硝基二乙胺(NDEA)是一种有效的肝癌性二烷基亚硝胺。它主要存在于烟草烟雾、水、切达干酪、腌制油炸食品和许多酒精饮料中。NDEA与DNA修复/复制相关的核酶的变化相关。它会导致所有动物物种中的多种肿瘤。[4]其主要靶器官是鼻腔、气管、肺、食道和肝脏。

包裝

包装于100mL带有硅/PTFE胶垫和铝质撕裂密封的血清瓶中。

注意

通过注入任何相容的溶剂可在不暴露内容物的情况下制备任何所需强度的溶液。

重構

将内容物溶解在100mL溶剂中,可得到1%的溶液。

法律資訊

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC

產品號碼
描述
訂價

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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文章

DNA 損傷和修復機制對維持 DNA 的完整性至關重要。細胞 DNA 的損害與突變、癌症的發展等有關。

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

Questions

1–7 of 7 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  4. Is Product N0258, N-nitrosoethylamine, a solid or a liquid? Why is the package size expressed in grams?

    1 answer
    1. This product is neat liquid. The package size is in grams but can be converted to volume by using the density of 0.95 g/mL.

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  5. What is the solubility of Product N0258, N-Nitrosodiethylamine?

    1 answer
    1. According to the chemicals encyclopedia published by the Royal Society of Chemistry, 12th edition, this compound is soluble in water, ether and alcohol.

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  6. How does the storage temperature relate to shipping conditions?

    1 answer
    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  7. How can I store solutions of Product N0258, N-Nitrosodiethylamine?

    1 answer
    1. The product should be stable in neutral solution, but it is unstable with strong acid and heat. N-nitroso amine compounds are relatively stable when dissolved in aqueous solutions at physiological pH. But they are generally light sensitive, so stock solutions should be kept cool and protected from light.

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