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PHR1019

Supelco

苯甲醇

Benzyl alcohol

Pharmaceutical Secondary Standard; Certified Reference Material

同義詞:

苯甲醇

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About This Item

線性公式:
C6H5CH2OH
CAS號碼:
100-51-6
分子量：:
108.14
Beilstein:
878307
EC號碼:
202-859-9
MDL號碼:
MFCD00004599
分類程式碼代碼:
12352104
eCl@ss:
39023110
PubChem物質ID:
329823050
NACRES:
NA.24
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等級

certified reference material
pharmaceutical secondary standard

品質等級

300

agency

traceable to Ph. Eur. Y0000167
traceable to USP 1061901

蒸汽密度

3.7 (vs air)

蒸汽壓力

13.3 mmHg ( 100 °C)
3.75 mmHg ( 77 °C)

API 家族

benzalkonium chloride

CofA

current certificate can be downloaded

自燃溫度

817 °F

儲存期限

~3 yr

技術

HPLC: suitable
gas chromatography (GC): suitable

折射率

n20/D 1.539 (lit.)

bp

203-205 °C (lit.)

mp

−16-−13 °C (lit.)

密度

1.045 g/mL at 25 °C (lit.)

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-30°C

SMILES 字串

OCc1ccccc1

InChI

1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2

InChI 密鑰

WVDDGKGOMKODPV-UHFFFAOYSA-N

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相關類別

一般說明

用于质量控制的制药二级标准品，为制药实验室和制造商制备内部工作标准提供了一种方便、高性价比的替代方案。
苯甲醇在药物制剂中作为防腐剂（浓度高达2%）和增溶剂（浓度为5%）。可有效抑制革兰氏阳性菌。[1]

應用

苯甲醇可作为药物参考标准品，用于通过色谱分析法[2]和分光光度测定法测定制药配方中的分析物。[3][4]
这些二级标准品是经认证过的有证标准物质（CRM）。它们适用于多种分析应用，包括但不限于药物释放测试、药物的定性和定量分析方法开发、食品和饮料质量控制检测以及其他校准需求。

分析報告

这些二级标准提供了有效的美国药典、欧洲药典和英国药典一级标准的多重可追溯性。

其他說明

该认证参考物质（CRM）根据ISO 17034 和 ISO/IEC 17025进行生产和认证。有关此CRM使用的所有信息均可在分析证书上找到。

腳註

要查看该材料的分析证书示例，请在下面的栏位中输入 LRAC1678。这只是一个示例证书，可能不是您收到的批次。

推薦產品

在我们的NMR在线平台ChemisTwin®上可以找到本品对应的数字化标准物质。您可使用ChemisTwin®上的数字等效品鉴定您的样品并进行定量分析（使用数字化外标）。可查看该物质的NMR谱图，只需点击几次鼠标，就能进行在线样品比对。欢迎点击了解更多，开启免费试用之旅。

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H302 + H332,H319

危險分類

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

213.8 °F - DIN 51758

閃點（°C）

101 °C - DIN 51758

從最近期的版本中選擇一個：

分析證明 (COA)

Lot/Batch Number

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SAFC

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Simultaneous determination of bifonazole and benzyl alcohol in pharmaceutical formulations by reverse-phase HPLC.
Cudina OA, et al.
Chromatographia, 61(7-8), 415-418 (2005)
Full spectrum and selected spectrum based multivariate calibration methods for simultaneous determination of betamethasone dipropionate, clotrimazole and benzyl alcohol: Development, validation and application on commercial dosage form.
Darwish HW, et al.
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 169, 50-57 (2016)
Simultaneous spectrophotometric determination of piroxicam and benzyl alcohol in gel forms.
Goger NG, et al.
Chem. Anal. (Warsaw), 50(6), 1059-1059 (2005)
Simultaneous spectrophotometric determination of benzyl alcohol and diclofenac in pharmaceuticals using methods based on the first derivative of the optical density ratio.
Ghasemi J, et al.
Pharmaceutical Chemistry Journal, 39(12) (2005)
Béatrice Hechler et al.
The Journal of pharmacology and experimental therapeutics, 314(1), 232-243 (2005-03-29)
Our aim was to determine whether the newly described P2X1 antagonist NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt] could selectively antagonize the platelet P2X1 receptor and how it affected platelet function. NF449 inhibited alpha,beta-methyleneadenosine 5'-triphosphate-induced shape change (IC50 = 83 +/- 13
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Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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