Y1521

YS-49 monohydrate

≥98% (HPLC)

• Synonim(y): 1,2,3,4-Tetrahydro-1-(1-naphthalenylmethyl)-6,7-Isoquinolinediol hydrobromide monohydrate
• Wzór empiryczny (zapis Hilla): C₂₀H₁₉NO₂ · HBr · H₂O
• Numer CAS: 132836-42-1
• Masa cząsteczkowa: 404.30
• Numer MDL: MFCD16875442
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 329831588
• NACRES: NA.77

Właściwości

• Próba: ≥98% (HPLC)
• Postać: solid
• rozpuszczalność: H₂O: >10 mg/mL
• temp. przechowywania: 2-8°C
• ciąg SMILES: O.Br.Oc1cc2CCNC(Cc3cccc4ccccc34)c2cc1O
• InChI: 1S/C20H19NO2.BrH.H2O/c22-19-11-15-8-9-21-18(17(15)12-20(19)23)10-14-6-3-5-13-4-1-2-7-16(13)14;;/h1-7,11-12,18,21-23H,8-10H2;1H;1H2
• Klucz InChI: QHCUNMLYODPTIU-UHFFFAOYSA-N

Opis

Działania biochem./fizjol.

YS-49 protects cells from oxidant injury; anti-inflammatory agent; activator of PI3K/Akt signaling. YS-49, an analog of higenamine, induces heme oxygenase (HO-1) in endothelial cells and protects cells from oxidant injury. The compound was reported to inhibit Ang II-stimulated VSMC proliferation through HO-1 production, which inhibits both the JNK pathway and ROS production. A study (JPET) reported that CKD712 (S-YS-49) confer cardiac protection and anti-inflammatory via activation of the PI3K signal pathway. These effects were antagonized by a PI3K inhibitor, wortmannin.

Cechy i korzyści

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H302
• Klasyfikacja zagrożeń: Acute Tox. 4 Oral
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable