SRP5335

PP2C-α, active, GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

• Synonim(y): FLJ42306, MGC9201, PP2C-ALPHA, PP2CA, PPM1A
• Numer CAS: 362690-38-8
• Kod UNSPSC: 12352200
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• rekombinowane: expressed in baculovirus infected Sf9 cells
• Próba: ≥70% (SDS-PAGE)
• Postać: buffered aqueous glycerol solution
• aktywność właściwa: 960-1440 nmol/min·mg
• masa cząsteczkowa: ~105 kDa
• numer dostępu NCBI: NM_021003
• Zastosowanie: cell analysis
• Warunki transportu: dry ice
• temp. przechowywania: −70°C
• informacje o genach: human ... PPM1A(5494)

Opis

Opis ogólny

Protein phosphatase 2C-α (PP2C-α), also called protein phosphatase, Mg²⁺/Mn²⁺ dependent 1A (PPM1A), is a member of the family of Ser/Thr protein phosphatases and is composed of a catalytic subunit and a constant regulatory subunit. PP2C-α is highly expressed in heart and skeletal muscle. The gene encoding this protein is localized on human chromosome 4q12.

Działania biochem./fizjol.

Protein phosphatase 2C-α (PP2C-α) or PPM1A is known to be negative regulators of cell stress response pathways. It has been reported to negatively regulate TGF-β signaling pathway and cell cycle. PP2C-α has been shown to dephosphorylate cyclin-dependent kinases (CDKs) and it may be involved in cell cycle control. It modulates cell migration and invasion. Overexpression of PP2C-α is reported to cause cell-growth arrest or cell death.

Postać fizyczna

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

Uwaga dotycząca przygotowania

After opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 10 - Combustible liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable