SML0650

Risedronate sodium

Name: Risedronate sodium
Brand: SIGMA
Price: 499.8 PLN

≥97% (HPLC)

Synonim(y):

P,P′-[1-Hydroxy-2-(3-pyridinyl)ethylidene]bis-phosphonic acid sodium, Sodium risedronate, [1-Hydroxy-2-(3-pyridinyl)ethylidene]bis[phosphonic acid] monosodium salt

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50 MG

499,80 zł

Cena katalogowa588,00 złZaoszczędź 15%

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Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):

C₇H₁₀NO₇P₂ · Na

Numer CAS:

115436-72-1

Masa cząsteczkowa:

305.09

UNSPSC Code:

41106300

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

H₂O: 5 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

[Na+].[P](=O)([O-])(O)[C@]([P](=O)(O)O)(O)Cc1cnccc1

InChI

1S/C7H11NO7P2.Na/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6;/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15);/q;+1/p-1

InChI key

DRFDPXKCEWYIAW-UHFFFAOYSA-M

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Ta pozycja	SML1289	A4978	SML2159
Sigma-Aldrich SML0650 Risedronate sodium	Sigma-Aldrich SML1289 Desferrithiocin sodium salt	Sigma-Aldrich A4978 Alendronate sodium trihydrate	Sigma-Aldrich SML2159 Minodronic acid monohydrate
assay ≥97% (HPLC)	assay ≥98% (HPLC)	assay ≥97% (NMR)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
storage temp. room temp	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility H₂O: 5 mg/mL, clear (warmed)	solubility H₂O: 15 mg/mL, clear	solubility water, double-distilled: 10 mg/mL	solubility 0.1 M NaOH: 2 mg/mL, clear (warmed)
color white to beige	color faintly yellow to dark yellow	color white	color white to beige

Biochem/physiol Actions

Risedronate sodium is a bisphosphonate bone resorption inhibitor.

Risedronate sodium is a bisphosphonate bone resorption inhibitor. It has an affinity for hydroxyapatite crystals in bone and acts as an antiresorptive agent and is an inhibitor of farnesyl diphosphate (FPP) synthase, which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. Risedronate sodium has been used to treat postmenopausal osteoporosis and Paget′s disease.

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pictograms

GHS07

signalword

Warning

hcodes

H302 + H312 + H332

pcodes

P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

0000472550

0000220154

0000185944

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Odwiedź Bibliotekę dokumentów

Risedronate positively affects osteogenic differentiation of human mesenchymal stromal cells.

Antonio Casado-Díaz et al.

Archives of medical research, 44(5), 325-334 (2013-07-23)

Bisphosphonates are widely used for the treatment of bone pathologies, mainly due to their ability to inhibit osteoclastic activity and thus bone resorption. Yet, their potential effect on bone formation is unclear. Our aim was to determine whether risedronate can

No effect of risedronate on articular cartilage damage in the Dunkin Hartley guinea pig model of osteoarthritis.

J S Thomsen et al.

Scandinavian journal of rheumatology, 42(5), 408-416 (2013-03-27)

To investigate whether treatment with a bisphosphonate would influence the subchondral bone plate stiffness and the development of cartilage damage in Dunkin Hartley guinea pigs, which develop osteoarthritis (OA) spontaneously. Fifty-six 3-month-old male Dunkin Hartley guinea pigs were randomized into

Analysis of docetaxel therapy in elderly (≥70 years) castration resistant prostate cancer patients enrolled in the Netherlands Prostate Study.

F L Gerritse et al.

European journal of cancer (Oxford, England : 1990), 49(15), 3176-3183 (2013-07-16)

Prostate cancer truly is an age-associated disease. Due to the increased life expectancy and more sensitive diagnostic techniques in the Western world, prostate cancer is diagnosed more frequently and with rapidly increasing incidence and prevalence rates. However, age above 65

Persistence with osteoporosis medication among newly-treated osteoporotic patients.

Job F M van Boven et al.

Journal of bone and mineral metabolism, 31(5), 562-570 (2013-04-12)

Low persistence with osteoporosis medication is associated with higher fracture risk. Previous studies estimated that 1-year persistence with osteoporosis medication is low. Our aim was to study persistence with osteoporosis medication among patients with long-term follow-up (to 5 years). The InterAction

Effectiveness of risedronate and alendronate on nonvertebral fractures: an observational study through 2 years of therapy.

R Lindsay et al.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 24(8), 2345-2352 (2013-04-25)

This observational study showed that after 2 years, both risedronate and alendronate lowered the risk of hip and nonvertebral fractures compared with patients filling in a single bisphosphonate prescription. Post hoc analyses of the placebo-controlled trials suggested earlier effects for

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Numer pozycji handlu globalnego

SKU	NUMER GTIN
SML0650-50MG	04061837101205

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Risedronate sodium