P4904

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine hydrate

≥98%

• Synonim(y): 1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine, 1-O-Palmityl-2-acetyl-sn-glycero-3-phosphocholine monohydrate, 2-Acetyl-1-hexadecyl-sn-glycero-3-phosphocholine, 3-sn-Phosphatidylcholine, 1-hexadecyl-2-acetyl, PAF(C₁₆), Platelet activating factor
• Wzór empiryczny (zapis Hilla): C₂₆H₅₄NO₇P · xH₂O
• Numer CAS: 74389-68-7
• Masa cząsteczkowa: 523.68 (anhydrous basis)
• Beilstein: 3574588
• Numer MDL: MFCD00150679
• Kod UNSPSC: 12352211
• Identyfikator substancji w PubChem: 24898570
• NACRES: NA.77

Właściwości

• Poziom jakości: 200
• Próba: ≥98%
• Formularz: powder
• temp. przechowywania: −20°C
• ciąg SMILES: O.CCCCCCCCCCCCCCCCOC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(C)=O
• InChI: 1S/C26H54NO7P.H2O/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)28)24-33-35(29,30)32-22-20-27(3,4)5;/h26H,6-24H2,1-5H3;1H2/t26-;/m1./s1
• Klucz InChI: HFMSDOHEENWULV-UFTMZEDQSA-N

Opis

Zastosowanie

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine has been used:

• to study its effects on phagocytic activity and production of superoxide anion in equine alveolar macrophage and blood neutrophils[1]
• to study its protective effects against cisplatin-induced cell death in a human melanoma cell line in vitro[2]
• to determine its effects on cervical ripening and leukocyte infiltration in rat models[3]

Działania biochem./fizjol.

β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine or platelet-activating factor (PAF), is a phospholipid[4], and a pro-inflammatory lipid mediator.[5] It acts as a ligand for G protein-coupled platelet-activating factor (PAF) receptors and participates in several biological processes such as airway constriction, hypotension, platelet activation, and increased vascular permeability.[5] PAF is released by various cells such as platelets, neutrophils, endothelial cells, and monocytes/macrophages. The levels of PAF are low in the blood due to its rapid metabolism by PAF acetylhydrolase and low production.[6]

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)