SRP3136

PAF-AH human

Name: PAF-AH human
Brand: SIGMA

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE), ≥95% (HPLC), suitable for cell culture

Synonim(y):

1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, LDL-associated phospholipase A2, PAF 2-acylhydrolase, PAF acetylhydrolase

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Informacje o tej pozycji

NACRES:

NA.32

UNSPSC Code:

12352202

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biological source

human

recombinant

expressed in HEK 293 cells

assay

≥95% (HPLC), ≥95% (SDS-PAGE)

form

lyophilized

potency

≤0.1 ng/mL ED₅₀

mol wt

47-55 kDa

packaging

pkg of 20 μg

technique(s)

cell culture | mammalian: suitable

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

Q13093

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... PLA2G7(7941)

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Ta pozycja	SRP3145	SRP3007	P1588
Sigma-Aldrich SRP3136 PAF-AH human	Sigma-Aldrich SRP3145 PLGF-I human	Sigma-Aldrich SRP3007 Angiopoietin-1 human	Sigma-Aldrich P1588 Placenta Growth Factor human
assay ≥95% (HPLC), ≥95% (SDS-PAGE)	assay ≥95% (HPLC), ≥95% (SDS-PAGE)	assay ≥95% (HPLC), ≥95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
biological source human	biological source human	biological source human	biological source human
shipped in wet ice	shipped in wet ice	shipped in wet ice	shipped in dry ice
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −70°C
packaging pkg of 20 μg	packaging pkg of 25 μg	packaging pkg of 5 μg	packaging pkg of 10 and 50 μg

General description

Recombinant PAF-AH is a 420 amino acid glycoprotein which migrates with an apparent molecular mass of 47-55kDa by SDS-PAGE analysis.

Biochem/physiol Actions

Platelet Activating Factor (PAF) is a biologically active phospholipid, which exerts primarily proinflammatory activities by specifically signaling through G-protein-coupled receptors on platelets, neutrophils, and monocytes. Platelet activating factor acetylhydrolase (PAF-AH) is a secreted protein that mediates PAF activity by specifically catalyzing hydrolysis of the "sn2" ester bond, resulting in the conversion of PAF to the biologically inactive lyso-PAF. PAF-AH can also interact with LDL (low density lipoprotein) particles to induce the hydrolysis of LDL associated, oxidized phospholipids, generating lysophosphatidylcholine (lyso-PC) and other lysophospholipids. High levels of PAF-AH in plasma can be an indication of resistant hypertension. Polymorphism in PAF-AH gene at A379V might be linked with ischemic stroke susceptibility.

Physical form

Lyophilized from 10 mM Tris, pH 8.5.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Other Notes

FDWQYINPVA HMKSSAWVNK IQVLMAAASF GQTKIPRGNG PYSVGCTDLM FDHTNKGTFL RLYYPSQDND RLDTLWIPNK EYFWGLSKFL GTHWLMGNIL RLLFGSMTTP ANWNSPLRPG EKYPLVVFSH GLGAFRTLYS AIGIDLASHG FIVAAVEHRD RSASATYYFK DQSAAEIGDK SWLYLRTLKQ EEETHIRNEQ VRQRAKECSQ ALSLILDIDH GKPVKNALDL KFDMEQLKDS IDREKIAVIG HSFGGATVIQ TLSEDQRFRC GIALDAWMFP LGDEVYSRIP QPLFFINSEY FQYPANIIKM KKCYSPDKER KMITIRGSVH QNFADFTFAT GKIIGHMLKL KGDIDSNVAI DLSNKASLAF LQKHLGLHKD FDQWDCLIEG DDENLIPGTN INTTNQHIML QNSSGIEKYN

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Klasa składowania

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certyfikaty analizy (CoA)

Lot/Batch Number

0416448

1008448

0608448

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population.

Yamada Y, et al.

Atherosclerosis, 150, 209-216 (2000)

Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions.

Mateen A Khan et al.

Nucleic acids research, 42(10), 6567-6577 (2014-04-15)

Metal ion binding was previously shown to destabilize IRE-RNA/IRP1 equilibria and enhanced IRE-RNA/eIF4F equilibria. In order to understand the relative importance of kinetics and stability, we now report rapid rates of protein/RNA complex assembly and dissociation for two IRE-RNAs with

Association of PLA2G7 gene polymorphisms with ischemic stroke in northern Chinese Han population.

Liu X, et al.

Clinical Biochemistry, 47, 404-408 (2014)

Biology of platelet-activating factor acetylhydrolase (PAF-AH, lipoprotein associated phospholipase A2).

Stafforini DM

Cardiovascular Drugs and Therapy, 23, 73-83 (2009)

Platelet-activating factor acetylhydrolase.

Hiroyuki Arai

Prostaglandins & other lipid mediators, 68-69, 83-94 (2002-11-16)

Platelet-activating factor (PAF) is one of the most potent lipid mediators and is involved in a variety of physiological events. The acetyl group at the sn-2 position of its glycerol backbone is required for its biological activity, and deacetylation of

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