G1660

Galanthamine hydrobromide

From plant (Ungeria victoris), ≥94% (HPLC), Cholinesterase inhibitor, powder

• Synonim(y): Galantamine hydrobromide
• Wzór empiryczny (zapis Hilla): C₁₇H₂₁NO₃ · HBr
• Numer CAS: 1953-04-4
• Masa cząsteczkowa: 368.27
• UNSPSC Code: 12352116
• PubChem Substance ID: 24895074
• NACRES: NA.32
• EC Number: 217-780-5
• MDL number: MFCD00067672

Właściwości

• Nazwa produktu: Galanthamine hydrobromide from Lycoris sp., ≥94% (HPLC)
• biological source: plant (Ungeria victoris)
• Quality Segment: 100
• assay: ≥94% (HPLC)
• form: powder
• mp: 270 °C
• solubility: DMSO: soluble 10 mg/mL, clear, colorless, water: soluble 20 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: Br[H].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24
• InChI: 1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
• InChI key: QORVDGQLPPAFRS-XPSHAMGMSA-N
• Gene Information: human ... ACHE(43)

Opis

General description

Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. This compound is used for the treatment of Alzheimer′s disease (AD).

Application

Galanthamine hydrobromide from Lycoris sp. has been used-

• as an AChE (acetylcholinesterase) inhibitor and positive control in acetylcholinesterase assay performed to determine the activity of AChE
• as a positive control in the screening of AChE inhibitors
• as a positive control in AChE inhibitory assay performed to determine the AChE-inhibitory activities of pyrithione and related sulfur-containing pyridine N-oxides

Biochem/physiol Actions

Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Informacja o środkach bezpieczeństwa

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Klasa składowania: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges