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Merck

F6008

Ficin from fig tree latex

lyophilized powder

Synonim(y):

Debricin, Ficain, higueroxyl delabarre

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100 UNITS

1020,00 zł

200 UNITS

1890,00 zł

1000 UNITS

7110,00 zł

1020,00 zł

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Informacje o tej pozycji

Numer CAS:
9001-33-6
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-599-1
MDL number:
MFCD00081597
Numer WE:
3.4.22.3 (BRENDA, IUBMB)
Specific activity:
≥1.0 units/mg protein
Biological source:
fig tree (latex)

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biological source

fig tree (latex)

form

lyophilized powder

specific activity

≥1.0 units/mg protein

mol wt

23.8 kDa

composition

Protein, 80-100% biuret

storage temp.

−20°C

Quality Level

300

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Ta pozycja
F4165P3375F4125
Ficin from fig tree latex lyophilized powder

Sigma-Aldrich

F6008

Ficin from fig tree latex

Ficin from fig tree latex powder, ≥0.1 unit/mg solid

Sigma-Aldrich

F4165

Ficin from fig tree latex

Papain from papaya latex crude powder, 1.5-10 units/mg solid

Sigma-Aldrich

P3375

Papain from papaya latex

Ficin from fig tree latex saline suspension, ≥1.0 units/mg protein (biuret)

Sigma-Aldrich

F4125

Ficin from fig tree latex

specific activity

≥1.0 units/mg protein

specific activity

≥0.1 unit/mg solid

specific activity

1.5-10 units/mg solid

specific activity

≥1.0 units/mg protein (biuret)

biological source

fig tree (latex)

biological source

fig tree (latex)

biological source

-

biological source

fig tree (latex)

form

lyophilized powder

form

powder

form

crude powder

form

saline suspension

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

mol wt

23.8 kDa

mol wt

23.8 kDa

mol wt

23.4 kDa

mol wt

23.8 kDa

Quality Level

300

Quality Level

200

Quality Level

200

Quality Level

200

General description

Extinction Coefficient: E1% = 21.0 (280 nm)
pI: 9.0

Application

Ficin from fig tree latex has been used:
  • in the proteolysis of tendon collagen
  • in the digestion of Chlorophyta Ulva rigida
  • to investigate it effect on protease-activated receptors 2 and 4 activation to induce itch in skin[1]

Biochem/physiol Actions

Ficin is classified as a thiol protease. It contains a single reactive cysteine at its active site. The amino acid homology of the active site is similar to that of papain. Ficin will cleave proteins at the carboxyl side of Gly, Ser, Thr, Met, Lys, Arg, Tyr, Ala, Asn, and Val. The reported Km for the chromogenic substrate pGlu-Phe-Leu-p-nitroanilide is 0.43 mM. Ficin is inhibited by iodoacetamide, iodoacetic acid, N-ethylmaleimide, mercuric chloride, DFP (diisopropyl fluorophosphate), TLCK (Na-p-Tosyl-lysine chloromethyl ketone), and TPCK (N-Tosyl-L-phenylalanine chloromethyl ketone). Ficin can be used to generate high yielding F (ab′)2 fragments from mouse IgG1.
Ficin is effective in disrupting the staphylococcal biofilms making it accessible antibiotics exposure.

Physical form

Lyophilized powder containing L-cysteine and trace EDTA

Preparation Note

This enzyme is soluble in water (10 mg/ml), yielding a clear solution.

Other Notes

One unit will produce a ΔA280 of 1.0 per min at pH 7.0 at 37°C when measuring TCA soluble products from casein in a final volume of 10 ml (1 cm light path).
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related product

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E3132

E-64, protease inhibitor

used together

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Klasa składowania

11 - Combustible Solids

wgk

WGK 1

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certyfikaty analizy (CoA)

Lot/Batch Number
0000482802
0000482801
0000482801
0000482802
0000416232

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Masz już ten produkt?

Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Generation of an artificial skin construct containing a non-degradable fiber mesh: a potential transcutaneous interface
Cahn F and Kyriakides TR
Biomedical Materials (Bristol, England), 3(3), 034110-034110 (2008)
Targeting microbial biofilms using Ficin, a nonspecific plant protease
Baidamshina DR, et al.
Scientific reports, 7, 46068-46068 (2017)
Yusei Takemoto et al.
Journal of cellular physiology, 234(2), 1689-1698 (2018-08-03)
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator for the induction of antioxidative genes and plays roles in diverse cellular functions. The roles of Nrf2 in muscle regeneration have been investigated, and both important and unimportant roles
Isolation and characterization of angiotensin I-converting enzyme (ACE) inhibitory peptides from Ulva rigida C. Agardh protein hydrolysate
Paiva L, et al.
Journal of functional foods, 26, 65-76 (2016)
A Aktypis et al.
Journal of applied microbiology, 84(4), 568-576 (1998-06-20)
ACA-DC 0040 produced an antimicrobial agent, which was named thermophilin T, active against several lactic acid bacteria strains of different species and food spoilage bacteria, such as Clostridium sporogenes C22/10 and Cl. tyrobutyricum NCDO-1754. The crude antimicrobial compound is sensitive
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Protokoły

Enzymatic Assay of Ficin (EC 3.4.22.3)

This procedure may be used for all Ficin products.

Questions

  1. What is this used for exactly? In lay terms please.

    1 answer

    1. Ficin is an enzyme that has a number of uses in several markets. As mentioned in the DESCRIPTION section of the product detail page, ficin from fig tree latex has been used:

      in the proteolysis of tendon collagen (tendons are softened in meat/muscles)
      in the digestion of Chlorophyta Ulva rigida (softens this algae which is used in 'sea salad' and animal feed)
      to investigate it's effect on protease-activated receptors 2 and 4 activation to induce itch in skin (studies indicate it can cause itching)
      in disrupting the staphylococcal biofilms, making it accessible antibiotics exposure. (Staph can be very resistant to antibiotics, particularly in 'biofilms'. Ficin digests or breaks down this film so that antibiotics are more effective.)

      It is also used in the food industry, primarily dairy products and is useful in clotting milk to aid in cheese production.
      Ficin has several medical uses, as well. This product is for research use only, however the link below describes some of the medical applications of Ficin:
      https://www.webmd.com/vitamins/ai/ingredientmono-141/ficin

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