D054

R(+)-SCH-23390 hydrochloride

≥98% (HPLC), solid

• Synonim(y): R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
• Wzór empiryczny (zapis Hilla): C₁₇H₁₈ClNO · HCl
• Numer CAS: 125941-87-9
• Masa cząsteczkowa: 324.24
• Numer MDL: MFCD00069249
• Kod UNSPSC: 12352200
• Identyfikator substancji w PubChem: 24277910
• NACRES: NA.77

Właściwości

• Poziom jakości: 100
• Próba: ≥98% (HPLC)
• Postać: solid
• aktywność optyczna: [α]/D +32.1°, c = 1 in DMF(lit.)
• warunki przechowywania: desiccated; protect from light
• kolor: white
• rozpuszczalność: H₂O: >5 mg/mL
• ciąg SMILES: Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
• InChI: 1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
• Klucz InChI: OYCAEWMSOPMASE-XFULWGLBSA-N
• informacje o genach: human ... DRD1(1812)

Opis

Zastosowanie

R(+)-SCH-23390 hydrochloride has been used:

• for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
• as a D1 receptor-selective antagonist for intracranial drug infusions
• as an antagonist of D1 receptor to study its effect on learning ability in fish

Działania biochem./fizjol.

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

Cechy i korzyści

This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informacje prawne

Sold with the permission of Schering-Plough.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 13 - Non Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)