52619

Hexamethyldisilazane

for GC derivatization, LiChropur^™, ≥99.0% (GC)

• Synonim(y): HMDS
• Wzór liniowy: (CH₃)₃SiNHSi(CH₃)₃
• Numer CAS: 999-97-3
• Masa cząsteczkowa: 161.39
• Beilstein: 635752
• Numer WE: 213-668-5
• Numer MDL: MFCD00008259
• Kod UNSPSC: 12000000
• Identyfikator substancji w PubChem: 329757861
• NACRES: NA.22

Właściwości

• klasa czystości: derivatization grade ((GC derivatization)); for GC derivatization
• Poziom jakości: 100
• Próba: ≥99.0% (GC)
• Formularz: liquid
• jakość: LiChropur^™
• przydatność reakcji: reagent type: derivatization reagent; reaction type: Silylations
• metody: gas chromatography (GC): suitable
• współczynnik refrakcji: n20/D 1.407 (lit.); n20/D 1.408
• bp: 125 °C (lit.)
• ciąg SMILES: C[Si](C)(C)N[Si](C)(C)C
• InChI: 1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3
• Klucz InChI: FFUAGWLWBBFQJT-UHFFFAOYSA-N

Opis

Opis ogólny

Hexamethyldisilazane (HMDS) is a commercially available, silylating agent,[1][2] which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.[2]

Zastosowanie

Learn more in the Product Information

Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites,[3] phenol, hydroquinone and catechol[4] in urine samples, mixtures of free fatty acids and metal soaps in paint samples[5] using gas chromatography/mass spectrometry (GC/MS).

Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

Cechy i korzyści

• HMDS is inexpensive and has a relatively low boiling point (124-127 °C).        
• It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.        
• The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

Inne uwagi

Important silylating agent[6][7]

Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

Informacje prawne

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS02,GHS06
• Hasło ostrzegawcze: Danger
• Zwroty wskazujące rodzaj zagrożenia: H225,H302 + H332,H311,H412
• Zwroty wskazujące środki ostrożności: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312
• Klasyfikacja zagrożeń: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2
• Kod klasy składowania: 3 - Flammable liquids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): 52.5 °F - closed cup
• Temperatura zapłonu (°C): 11.4 °C - closed cup
• Środki ochrony indywidualnej: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter