32460

Meropenem trihydrate

VETRANAL^®, analytical standard

• Synonim(y): (1R,5S,6S)-2-[(3S,5S)-5-(dimethylaminocarbonyl)pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid trihydrate
• Wzór empiryczny (zapis Hilla): C₁₇H₂₅N₃O₅S · 3H₂O
• Numer CAS: 119478-56-7
• Masa cząsteczkowa: 437.51
• NACRES: NA.24
• PubChem Substance ID: 329754224
• UNSPSC Code: 41116107
• MDL number: MFCD08600005

Właściwości

• grade: analytical standard
• Quality Level: 100
• product line: VETRANAL^®
• shelf life: limited shelf life, expiry date on the label
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• application(s): forensics and toxicology; pharmaceutical (small molecule)
• format: neat
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: O.O.O.C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(S[C@@H]3CN[C@@H](C3)C(=O)N(C)C)=C(N2C1=O)C(O)=O
• InChI: 1S/C17H25N3O5S.3H2O/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4;;;/h7-12,18,21H,5-6H2,1-4H3,(H,24,25);3*1H2/t7-,8-,9+,10+,11-,12-;;;/m1.../s1
• InChI key: CTUAQTBUVLKNDJ-OBZXMJSBSA-N

Opis

General description

Meropenem trihydrate (Meropenem) is a broad-spectrum carbapenem with antibacterial properties. It inhibits cell wall synthesis in both gram-negative and gram-positive bacteria.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Meropenem has been used as a reference standard in an experiment conducted to investigate the effects on in vivo efficacy caused due to chemical differences in three generic products of meropenem.

Meropenem penetrates cell walls and binds to penicillin-binding protein targets. It acts against aerobes and anaerobes including E. coli, Klebsiella, Clostridium, Enterococcus sp. It is a common cause of mild transient aminotransferase elevations and can rarely result in clinically apparent, cholestatic liver injury.

Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic active against both Gram-positive and Gram-negative bacteria.

Meropenem trihydrate is an ultra-broad spectrum beta-lactam antibiotic.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H334
• pcodes: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Klasa składowania: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable