MABC117

Anti-Podoplanin Antibody, clone NZ1.2

clone NZ1.2, from rat

• Synonim(y): Aggrus, Glycoprotein 36, Gp36, PA2.26 antigen, T1-alpha, T1A
• Kod UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Właściwości

• pochodzenie biologiczne: rat
• Poziom jakości: 100
• forma przeciwciała: purified antibody
• rodzaj przeciwciała: primary antibodies
• klon: NZ1.2, monoclonal
• reaktywność gatunkowa: human
• metody: immunohistochemistry: suitable; western blot: suitable
• izotyp: IgG2aκ
• numer dostępu NCBI: NP_001006625
• numer dostępu UniProt: Q86YL7
• Warunki transportu: wet ice
• docelowa modyfikacja potranslacyjna: unmodified
• informacje o genach: human ... PDPN(10630)

Opis

Opis ogólny

Human podoplanin (T1alpha-2, aggrus and gp36) is a 38 kDa type-1 transmembrane glycoprotein that consists of 162 amino acids, nine of which form the intracellular domain. The highly O-glycosylated extracellular domain contains a sialic acid that is linked to an alpha-2,3 galactose, which forms the main part of the protein’s carbohydrate moieties. It is expressed in a select variety of human tissues and organs, and is also found in lymphatic, but not blood vessel endothelium. While its mode of action remains unclear, podoplanin is suggested to play a critical role in several physiological processes and conditions such as cell migration, cytoskeleton organization, tissue development, and tissue repair, as well as in carcinogenesis and tumor cell invasion.

Specyficzność

This antibody detects Podoplanin at the PLAG domain.

Immunogen

Epitope: PLAG Domain

Protein sequence corresponding to the PLAG domain of human Podoplanin.

Zastosowanie

Anti-Podoplanin Antibody, clone NZ1.2 is an antibody against Podoplanin for use in WB, IH.

Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Podoplanin in human lung adenocarcinoma and colorectal tissue.

Research Category
Apoptosis & Cancer

Research Sub Category
Cytoskeleton

Jakość

Evaluated by Western Blot in human lung tissue lysate.

Western Blot Analysis: A 1:2,000 dilution of this antibody detected Podoplanin in 10 µg of human lung tissue lysate.

Opis wartości docelowych

~25 kDa observed.
4 isoforms are produced by alternative splicing, at molecular weights of ~17 kDa (isoform 1), ~18 kDa (isoform 2), ~25 kDa (isoform 3), and ~25 kDa (isoform 4).

Postać fizyczna

Format: Purified

Protein G Purified

Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Przechowywanie i stabilność

Stable for 1 year at 2-8°C from date of receipt.

Komentarz do analizy

Control
Human lung tissue lysate.

Oświadczenie o zrzeczeniu się odpowiedzialności

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 12 - Non Combustible Liquids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable