8.51012

HCTU

O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem^®

• Synonim(y): 2-(6-Chloro-1-H-benzotriazole-1-yl)-1,1,3,3-tetramethylaminium hexafluorophosphate, HCTU
• Wzór empiryczny (zapis Hilla): C₁₁H₁₅ClF₆N₅OP
• Numer CAS: 330645-87-9
• Masa cząsteczkowa: 413.69
• Numer MDL: MFCD04973268
• Kod UNSPSC: 12352107
• NACRES: NA.22

Właściwości

• Poziom jakości: 300
• linia produktu: Novabiochem^®
• Próba: ≥98% (HPLC)
• Formularz: powder
• przydatność reakcji: reaction type: Coupling Reactions
• producent / nazwa handlowa: Novabiochem^®
• mp: >185 °C
• Zastosowanie: peptide synthesis
• temp. przechowywania: 2-8°C
• ciąg SMILES: F[P-](F)(F)(F)(F)F.Clc1cc2[n](nnc2cc1)[O+]=C(N(C)C)N(C)C
• InChI: 1S/C11H15ClN5O.F6P/c1-15(2)11(16(3)4)18-17-10-7-8(12)5-6-9(10)13-14-17;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1
• Klucz InChI: ZHHGTMQHUWDEJF-UHFFFAOYSA-N

Opis

Opis ogólny

HCTU ^[1] is a novel aminium-based coupling reagent, analogous to HBTU, which in comparative studies was found to give superiort results to TBTU in the synthesis of difficult peptides ^[2], in hindered couplings ^[3], and cyclizations ^[4].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] O. Marder, et al. (2002) Chimica Oggi, 37.
^[2] G. Sabatino, et al. in ′Peptides 2002, Proceedings of the 27th European Peptide Symposium′, E. Benedetti & C. Pedone (Eds), Naples, Edizioni Ziino, 2002, pp. 272.
^[3] M. Gude & S. Barthélémy in ′Peptides 2002, Proceedings of the 27th European Peptide Symposium′, E. Benedetti & C. Pedone (Eds), Naples, Edizioni Ziino, 2002, pp. 122.
^[4] G. Sabatino, et al. in ′Peptide Revolution: Genomics, Proteomics & Therapeutics, , Proc. 18th American Peptide Symposium′, M. Chrev & T. K. Sawyer (Eds), Cardiff, American Peptide Society, 2003, pp. 49.

Zastosowanie

• High-throughput parallel synthesis optimization of Glucagon-like Peptide 1 receptor agonists: Describes the use of HCTU as a reactive coupling reagent in peptide synthesis, highlighting its effectiveness in the production of GLP-1 agonists. (Ramos-Colón et al., 2018).
• An efficient synthesis of quinoxaline derivatives using HCTU as catalyst in DMF: Outlines a novel method for synthesizing quinoxaline and its derivatives using HCTU, highlighting its catalytic properties in facilitating efficient chemical reactions. (Sasane et al., 2023).
• An efficient one-pot conversion of carboxylic acids into benzimidazoles via an HBTU-promoted methodology: Describes the use of HCTU in a methodology to convert carboxylic acids into benzimidazoles, noting its role alongside other carbodiimide agents. (Barasa and Yoganathan, 2018).

Powiązanie

Replaces: 01-62-0038

Komentarz do analizy

Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Water (K. F.): ≤ 0.50 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informacje prawne

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Piktogramy: GHS07
• Hasło ostrzegawcze: Warning
• Zwroty wskazujące rodzaj zagrożenia: H317
• Zwroty wskazujące środki ostrożności: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Klasyfikacja zagrożeń: Skin Sens. 1A
• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable