566661
SAG
≥95% (HPLC), liquid, smoothened agonist, Calbiochem®
Synonim(y):
InSolution Smoothened Agonist, SAG, SAG 1.3 in Solution, SAG1.3 in Solution
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About This Item
Wzór empiryczny (zapis Hilla):
C28H28ClN3OS · 2HCl · xH2O
Masa cząsteczkowa:
562.98 (anhydrous basis)
Kod UNSPSC:
12352200
NACRES:
NA.77
Polecane produkty
product name
Smoothened Agonist, SAG, InSolution, ≥95%, 10 mM aqueous solution
Poziom jakości
Próba
≥95% (HPLC)
Postać
liquid
producent / nazwa handlowa
Calbiochem®
warunki przechowywania
OK to freeze
protect from light
Warunki transportu
wet ice
temp. przechowywania
−20°C
Opis ogólny
A cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Hedgehog pathway activation (EC50 ∼3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations.
Opakowanie
Packaged under inert gas
Ostrzeżenie
Toxicity: Standard Handling (A)
Postać fizyczna
A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566660) in H₂O.
Rekonstytucja
Following initial thaw, aliquot and freeze (-20°C).
Inne uwagi
Meloni, A.R., et al. 2006. Mol. Cell. Biol.26, 7750.
Chen, W., et al. 2004. Science306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.
Chen, W., et al. 2004. Science306, 2257.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA99, 14071.
Frank-Kamenetsky, M., et al. 2002. J. Biol.1, 10.
Informacje prawne
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 2
Temperatura zapłonu (°F)
Not applicable
Temperatura zapłonu (°C)
Not applicable
Certyfikaty analizy (CoA)
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