528110-M

PIH

A cell-permeable, non-toxic tridendate iron (Fe3+) chelator of the aroyl hydrazone class.

• Synonim(y): PIH, pyridoxal isonicotinoyl hydrazone, Iron Chelator III
• Wzór empiryczny (zapis Hilla): C₁₄H₁₄N₄O₃
• Numer CAS: 737-86-0
• Masa cząsteczkowa: 286.29
• Kod UNSPSC: 12352200
• NACRES: NA.28

Właściwości

• Poziom jakości: 100
• Próba: ≥99% (HPLC)
• Postać: solid
• przydatność reakcji: reagent type: chelator
• producent / nazwa handlowa: Calbiochem^®
• warunki przechowywania: OK to freeze; protect from light
• kolor: yellow
• rozpuszczalność: DMSO: 5 mg/mL; slighlty acidic medium: soluble
• temp. przechowywania: 2-8°C
• InChI: 1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,17,19H,8H2,1H3,(H,18,21)/b12-7+
• Klucz InChI: HOYFGBFEIXEDEL-KPKJPENVSA-N

Opis

Opis ogólny

A cell-permeable, non-toxic tridendate iron (Fe³⁺) chelator of the aroyl hydrazone class. Even at low concentrations, highly effective in mobilizing Fe³⁺ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Deferoxamine Mesylate (Cat. No. 252750) but has greater access to mitochondrial iron. Also useful for the management of iron overload disease in experimental models. Inhibits the induction of heme containing indoleamine 2,3-dioxygenase activity.

A cell-permeable, non-toxic, iron (Fe³⁺) chelator of the aroyl hydrazone class that exhibits high chelation efficacy. Highly effective in mobilizing Fe³⁺ from cells and preventing its uptake from transferrin, even at low concentrations. Exhibits similar specificity and binding affinity as Desferrioxamine (Cat. No. 252750) but has greater access to mitochondrial iron. Prevents iron-mediated oxyradical formation and minimizes tissue damage. Reported to useful in studies of the management of iron overload disease. Inhibits the induction of heme-containing indoleamine 2,3-dioxygenase activity.

Ostrzeżenie

Toxicity: Standard Handling (A)

Rekonstytucja

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C. Acidic stock solutions are stable for up to 2 months at -20°C.

Inne uwagi

Buss, J.L., et al. 2002. Biochem. Pharmacol.64, 1689.
Thomas, S.R., et al. 2001. J. Immunol.166, 6332.
Hermes-Linda, M., et al. 2000. Biochim. Biophys. Acta1523, 154.
Blaha, K., et al. 1998. Blood11, 4368.
Richardson, D.R., and Ponka, P. 1998. J. Lab. Clin. Med.131, 306.
Richardson, D.R.,et al. 1995. Blood86, 4295.
Richardson, D.R., et al. 1994. J. Lab. Clin. Med.124, 660.
Ponka, P., et al. 1988. Biochim. Biophys. Acta967, 122.
Ponka, P., et al. 1984. Biochim. Biophys. Acta802, 477.
Ponka, P., et al. 1979. FEBS Lett.97, 317.

Informacje prawne

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 1
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable