The recommended long term storage temperature for the product is -20°C. No formal studies have been performed to determine how many times the solution can be thawed and refrozen at -20°C, nor is solution stability data available for the product once it has been diluted. Given this absence of data, it would be best to store the product in single use aliquots.
Przejdź do
C1359
Calcein AM solution
≥90% purity (HPLC), solution
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| Gabaryty przesyłki | SKU | Dostępność | Cena netto |
|---|---|---|---|
| 100 μL | Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności | 2440,00 zł |
Informacje o tej pozycji
Wzór empiryczny (zapis Hilla):
C46H46N2O23
Numer CAS:
Masa cząsteczkowa:
994.86
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12171500
EC Number:
200-664-3
MDL number:
2440,00 zł
Skontaktuj się z Obsługą Klienta, aby uzyskać informacje na temat dostępności
Pomoc techniczna
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Pozwól nam pomócNazwa produktu
Calcein AM solution, 4 mM in DMSO, ≥90% (HPLC), solution
Quality Segment
assay
≥90% (HPLC)
form
solution
concentration
4 mM in DMSO
technique(s)
titration: suitable
color
colorless, white to off-white
λmax
491-497 nm
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
−20°C
SMILES string
CC(=O)OCOC(=O)CN(CC(=O)OCOC(C)=O)Cc1c(OC(C)=O)ccc2c1Oc3c(CN(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)c(OC(C)=O)ccc3C24OC(=O)c5ccccc45
InChI
1S/C46H46N2O23/c1-25(49)60-21-64-39(55)17-47(18-40(56)65-22-61-26(2)50)15-32-37(68-29(5)53)13-11-35-43(32)70-44-33(16-48(19-41(57)66-23-62-27(3)51)20-42(58)67-24-63-28(4)52)38(69-30(6)54)14-12-36(44)46(35)34-10-8-7-9-31(34)45(59)71-46/h7-14H,15-24H2,1-6H3
InChI key
XKFSBWQWNMZWFA-UHFFFAOYSA-N
Application
In cells, calcein AM solution has been used in calcein-AM dye transfer assay. It has been used for the staining of cells to study quantification of cell-migration. It has been used to study cytotoxic effects of drugs in cells.[1]
Biochem/physiol Actions
Calcein AM is a membrane permeable nonfluorescent molecule. It is converted to fluorescent calcein by intracellular esterases. Calcein has limited membrane permeability. Calcein AM is also a substrate for p-glycoprotein (Pgp). Presence of Pgp results in efflux of calcein AM and thereby decreases cellular fluorescence. On the other hand, presence of Pgp inhibitor increases cellular entry of calcein AM and thereby increases cellular fluorescence. Calcein AM plays an important role in early drug discovery.
Fluorescent cell permeable derivative of calcein.
Physical form
Solution in 0.4% Calcein AM and 99.6% DMSO.
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Ta pozycja | |||
|---|---|---|---|
| technique(s) titration: suitable | technique(s) - | technique(s) - | technique(s) - |
| concentration 4 mM in DMSO | concentration - | concentration - | concentration - |
| color colorless, white to off-white | color - | color - | color off-white |
| form solution | form solid | form - | form solid |
| application(s) diagnostic assay manufacturing | application(s) - | application(s) - | application(s) - |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
Klasa składowania
10 - Combustible liquids
wgk
WGK 2
flash_point_f
185.0 °F - closed cup
flash_point_c
85 °C - closed cup
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Numer pozycji handlu globalnego
| SKU | NUMER GTIN |
|---|---|
| C1359-100UL | 04061833467435 |
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Once thawed, can the solution be frozen again? If yes, should the aliquots be made?
1 answer-
Helpful?
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