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444151

Nutlin-3

InSolution, ≥98%, Racemic, potent and selective MDM2 antagonist

Synonim(y):

InSolution Nutlin-3, Racemic, MDM2 Inhibitor IV

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Gabaryty przesyłkiSKUDostępnośćCena netto
1 mg

Przewidywany termin wysyłki11 maja 2026zKuehne + Nagel Sp. z o.o.

530,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C30H30Cl2N4O4
Masa cząsteczkowa:
581.49
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

530,00 zł

Przewidywany termin wysyłki11 maja 2026Szczegóły

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Quality Level

100

assay

≥98% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

shipped in

wet ice

storage temp.

−20°C

General description

A cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.

Packaging

Packaged under inert gas

Physical form

A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Thompson, T., et al. 2004. J. Biol. Chem.279, 53015.
Vassilev, L.T., et al. 2004. Science303, 844.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)
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Ta pozycja
444143528101361552
Nutlin-3 InSolution, ≥98%, Racemic, potent and selective MDM2 antagonist

Sigma-Aldrich

444151

Nutlin-3

MDM2 Antagonist, Nutlin-3, Racemic The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Cancer applications.

Sigma-Aldrich

444143

MDM2 Antagonist, Nutlin-3, Racemic

PI-103 InSolution, ≥97%, potent ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR

Sigma-Aldrich

528101

PI-103

GSK-3 Inhibitor IX InSolution, ≥97%

Sigma-Aldrich

361552

GSK-3 Inhibitor IX

form

liquid

form

solid

form

liquid

form

liquid

assay

≥98% (HPLC)

assay

≥98% (TLC and HPLC)

assay

≥97% (HPLC)

assay

≥97% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage condition

OK to freeze, protect from light, desiccated (hygroscopic)

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

Klasa składowania

10 - Combustible liquids

wgk

WGK 2

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certyfikaty analizy (CoA)

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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.

Odwiedź Bibliotekę dokumentów

Christophe Le Clorennec et al.
International journal of molecular sciences, 24(18) (2023-09-28)
Neuroblastoma (NB) is a pediatric malignancy originating from neural crest cells of the sympathetic nervous system that accounts for 15% of all pediatric cancer deaths. Despite advances in treatment, high-risk NB remains difficult to cure, highlighting the need for novel
B Lamprecht et al.
The British journal of dermatology, 167(2), 240-246 (2012-03-06)
Primary cutaneous T-cell lymphomas (CTCLs) are a heterogeneous group with Sézary syndrome (SS) as one of the most aggressive variants. Recently, we identified a loss of E2A as a recurrent event in SS, which enhanced proliferation via upregulation of the
Anthony M Pettinato et al.
Cell reports, 35(5), 109088-109088 (2021-05-06)
Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization using fluorescently tagged cyclin B1 and cardiac troponin T.

Numer pozycji handlu globalnego

SKUNUMER GTIN
444151-1MG04055977205466

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