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371962

H-89, Dihydrochloride

≥99% (HPLC), protein kinase A inhibitor, liquid

Synonim(y):

InSolution H-89, Dihydrochloride, N-[2-(( p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III, N-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III

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Gabaryty przesyłkiSKUDostępnośćCena netto
1 mg

Dostępne do wysyłki DZISIAJzKuehne + Nagel Sp. z o.o.

697,00 zł

Informacje o tej pozycji

Wzór empiryczny (zapis Hilla):
C20H20BrN3O2S
Masa cząsteczkowa:
446.36
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥99% (HPLC)
Form:
liquid
Quality level:
100
Storage condition:
OK to freeze, protect from light

697,00 zł

Dostępne do wysyłki DZISIAJSzczegóły

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Nazwa produktu

H-89, Dihydrochloride, InSolution 10 mM, ≥99%, reversible ATP-competitive inhibitor of protein kinase A

Quality Level

100

assay

≥99% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

shipped in

wet ice

storage temp.

−20°C

General description

A solution of H-89, Dihydrochloride (Cat. No. 371963) in anhydrous DMSO. H-89 is a cell-permeable selective and potent inhibitor of protein kinase A (Ki = 48 nM). Inhibits other kinases at several fold higher concentrations: myosin light chain kinase (Ki = 28.3 µM), Ca2+/calmodulin-dependent protein kinase II (Ki = 29.7 µM), protein kinase C (Ki = 31.7 µM), casein kinase I (Ki = 38.3 µM), and Rho Kinase II (IC50 = 270 nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs), such as GEFI or Epac (exchange protein directly activated by cAMP) and GEFII. Reported to induce neurite formation in NG 108-15 cells (~1 µM) by blocking the action of Rho kinase II.

Biochem/physiol Actions

Cell permeable: no
Primary Target
PKA
Product does not compete with ATP.
Reversible: no
Target Ki: 48 nM against protein kinase A

Packaging

Packaged under inert gas

Physical form

A 10 mM (1 mg/193 µl) solution of H-89, 2HCl (Cat. No. 371963) in DMSO.

Preparation Note

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Leemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther.300, 1000.
Davies, S.P. et al. 2000. Biochem. J.351, 95.
de Rooij, J., et al. 1998. Nature.396, 474.
Kawasaki, H., et al. 1998. Science.282, 2275.
Findik, D., et al. 1995. J. Cell. Biochem.57, 12.
Hidaka, H., and Kobayashi, R. 1992. Annu. Rev. Pharmacol. Toxicol.32, 377.
Geilen, C.C., et al. 1992. FEBS Lett.309, 381.
Chijiwa, T., et al. 1990. J. Biol. Chem.265, 5267.
Combest, W.L., et al. 1988. J. Neurochem.51, 1581.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Irritant (B)
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Ta pozycja
B1427567731239825
H-89, Dihydrochloride InSolution 10 mM, ≥99%, reversible ATP-competitive inhibitor of protein kinase A

Sigma-Aldrich

371962

H-89, Dihydrochloride

H-89 dihydrochloride hydrate ≥98% (HPLC), powder

Sigma-Aldrich

B1427

H-89 dihydrochloride hydrate

Sphingosine Kinase Inhibitor The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

Sigma-Aldrich

567731

Sphingosine Kinase Inhibitor

AMD3100 InSolution, ≥98%, 50 mM aqueous solution, CXCR4 antagonist I

Sigma-Aldrich

239825

AMD3100

form

liquid

form

powder

form

solid

form

liquid

assay

≥99% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−70°C

storage condition

OK to freeze, protect from light

storage condition

-

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

storage condition

OK to freeze, avoid repeated freeze/thaw cycles, protect from light

Klasa składowania

10 - Combustible liquids

wgk

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

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SKUNUMER GTIN
371962-1MG04055977213515

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